Matches in SemOpenAlex for { <https://semopenalex.org/work/W2417477586> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2417477586 endingPage "6" @default.
- W2417477586 startingPage "125" @default.
- W2417477586 abstract "A hairpin ribozyme (HR112) and two hammerhead ribozymes (RZ115 and RZ119) containing a 5'C(UUCG)G3' loop were designed to cleave the long terminal repeat (LTR) of HIV-1. When the ribozyme catalyzed RNA cleavage reaction for a chemically synthesized 19 mer (LTR 19) was measured, the t 1/2 value of LTR 19 mediated by RZ115 was smaller than that of the RZ119 case. Moreover, the transformed CEM cells harboring the gene encoding these ribozymes were challenged with a HIV-1IIIB strain, two ribozymes, HR112 and RZ119 possessed strong anti-HIV-1 activity. However, the anti-HIV-1 activity displayed by RZ115 was weak. On the basis of secondary structure predictions of the RNA transcribed with the gene encoding ribozymes, the secondary structure of the transcribed RNA with RZ115 sequences was observed to be different from those with the other ribozymes. It has been demonstrated that the secondary structures of transcribed RNAs can possibly influence the anti-HIV-1 activity." @default.
- W2417477586 created "2016-06-24" @default.
- W2417477586 creator A5002424722 @default.
- W2417477586 creator A5007473811 @default.
- W2417477586 creator A5016495190 @default.
- W2417477586 creator A5025701219 @default.
- W2417477586 creator A5030266479 @default.
- W2417477586 creator A5044293886 @default.
- W2417477586 creator A5053178367 @default.
- W2417477586 creator A5071432270 @default.
- W2417477586 creator A5072772886 @default.
- W2417477586 creator A5088086085 @default.
- W2417477586 date "1995-01-01" @default.
- W2417477586 modified "2023-10-14" @default.
- W2417477586 title "Design and anti-HIV-1 activity of ribozymes that cleave HIV-1 LTR." @default.
- W2417477586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8841584" @default.
- W2417477586 hasPublicationYear "1995" @default.
- W2417477586 type Work @default.
- W2417477586 sameAs 2417477586 @default.
- W2417477586 citedByCount "3" @default.
- W2417477586 crossrefType "journal-article" @default.
- W2417477586 hasAuthorship W2417477586A5002424722 @default.
- W2417477586 hasAuthorship W2417477586A5007473811 @default.
- W2417477586 hasAuthorship W2417477586A5016495190 @default.
- W2417477586 hasAuthorship W2417477586A5025701219 @default.
- W2417477586 hasAuthorship W2417477586A5030266479 @default.
- W2417477586 hasAuthorship W2417477586A5044293886 @default.
- W2417477586 hasAuthorship W2417477586A5053178367 @default.
- W2417477586 hasAuthorship W2417477586A5071432270 @default.
- W2417477586 hasAuthorship W2417477586A5072772886 @default.
- W2417477586 hasAuthorship W2417477586A5088086085 @default.
- W2417477586 hasConcept C104317684 @default.
- W2417477586 hasConcept C107745601 @default.
- W2417477586 hasConcept C1342335 @default.
- W2417477586 hasConcept C150194340 @default.
- W2417477586 hasConcept C153911025 @default.
- W2417477586 hasConcept C159047783 @default.
- W2417477586 hasConcept C185592680 @default.
- W2417477586 hasConcept C19014433 @default.
- W2417477586 hasConcept C199491388 @default.
- W2417477586 hasConcept C2779792011 @default.
- W2417477586 hasConcept C3013748606 @default.
- W2417477586 hasConcept C30951146 @default.
- W2417477586 hasConcept C54355233 @default.
- W2417477586 hasConcept C552990157 @default.
- W2417477586 hasConcept C67705224 @default.
- W2417477586 hasConcept C76346623 @default.
- W2417477586 hasConcept C86803240 @default.
- W2417477586 hasConceptScore W2417477586C104317684 @default.
- W2417477586 hasConceptScore W2417477586C107745601 @default.
- W2417477586 hasConceptScore W2417477586C1342335 @default.
- W2417477586 hasConceptScore W2417477586C150194340 @default.
- W2417477586 hasConceptScore W2417477586C153911025 @default.
- W2417477586 hasConceptScore W2417477586C159047783 @default.
- W2417477586 hasConceptScore W2417477586C185592680 @default.
- W2417477586 hasConceptScore W2417477586C19014433 @default.
- W2417477586 hasConceptScore W2417477586C199491388 @default.
- W2417477586 hasConceptScore W2417477586C2779792011 @default.
- W2417477586 hasConceptScore W2417477586C3013748606 @default.
- W2417477586 hasConceptScore W2417477586C30951146 @default.
- W2417477586 hasConceptScore W2417477586C54355233 @default.
- W2417477586 hasConceptScore W2417477586C552990157 @default.
- W2417477586 hasConceptScore W2417477586C67705224 @default.
- W2417477586 hasConceptScore W2417477586C76346623 @default.
- W2417477586 hasConceptScore W2417477586C86803240 @default.
- W2417477586 hasIssue "34" @default.
- W2417477586 hasLocation W24174775861 @default.
- W2417477586 hasOpenAccess W2417477586 @default.
- W2417477586 hasPrimaryLocation W24174775861 @default.
- W2417477586 hasRelatedWork W1543278756 @default.
- W2417477586 hasRelatedWork W2001396871 @default.
- W2417477586 hasRelatedWork W2040265249 @default.
- W2417477586 hasRelatedWork W2059142404 @default.
- W2417477586 hasRelatedWork W2075682731 @default.
- W2417477586 hasRelatedWork W2162162459 @default.
- W2417477586 hasRelatedWork W2165032656 @default.
- W2417477586 hasRelatedWork W2321027494 @default.
- W2417477586 hasRelatedWork W2361845427 @default.
- W2417477586 hasRelatedWork W297249988 @default.
- W2417477586 isParatext "false" @default.
- W2417477586 isRetracted "false" @default.
- W2417477586 magId "2417477586" @default.
- W2417477586 workType "article" @default.