Matches in SemOpenAlex for { <https://semopenalex.org/work/W2417543344> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2417543344 endingPage "5" @default.
- W2417543344 startingPage "250" @default.
- W2417543344 abstract "Carnitine is a vital biologic substance facilitating fatty acids transport into mitochondria for ATP production. This study was to investigate the effects of pre-ischemic pharmacological preconditioning (PC) with L-carnitine (L-Car) on myocardial infarct size and cardiac functions in ischemic and reperfused isolated rat heart and meanwhile on left ventricular glycogen and lactate content. Isolated rat hearts were subjected to 30 min coronary artery occlusion followed by 120 min reperfusion. The hearts (n= 8-12) were perfused with L-Car (0.5-5 mM) only for 15 min before to 10 min after induction of ischemia. Preconditioning of the hearts with L-Car provided concentration-dependent cardioprotection as evidenced by improved postischemic ventricular functional recovery (developed pressure, left ventricular end diastolic pressure and coronary flow rate) and reduced myocardial infarct size (p<0.001). L-Car (2.5 mM) decreased both glycogen (p<0.001) and lactate (p>0.05) content in left ventricle during ischemia compared with the control. The results of this study demonstrate that L-Car pharmacologically precondition the hearts against ischemic and reperfusion injury in part by recovery of postischemic ventricular hemodynamic functions, depletion of glycogen and therefore reduction of lactate accumulation." @default.
- W2417543344 created "2016-06-24" @default.
- W2417543344 creator A5055846835 @default.
- W2417543344 creator A5061666481 @default.
- W2417543344 creator A5062818514 @default.
- W2417543344 creator A5081651440 @default.
- W2417543344 creator A5086064402 @default.
- W2417543344 date "2010-07-01" @default.
- W2417543344 modified "2023-09-26" @default.
- W2417543344 title "Pharmacological preconditioning with L-carnitine: relevance to myocardial hemodynamic function and glycogen and lactate content." @default.
- W2417543344 cites W1965808713 @default.
- W2417543344 cites W1992970653 @default.
- W2417543344 cites W2052790680 @default.
- W2417543344 cites W2105638106 @default.
- W2417543344 cites W2153579571 @default.
- W2417543344 cites W2166868657 @default.
- W2417543344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20566435" @default.
- W2417543344 hasPublicationYear "2010" @default.
- W2417543344 type Work @default.
- W2417543344 sameAs 2417543344 @default.
- W2417543344 citedByCount "6" @default.
- W2417543344 countsByYear W24175433442012 @default.
- W2417543344 countsByYear W24175433442013 @default.
- W2417543344 countsByYear W24175433442014 @default.
- W2417543344 crossrefType "journal-article" @default.
- W2417543344 hasAuthorship W2417543344A5055846835 @default.
- W2417543344 hasAuthorship W2417543344A5061666481 @default.
- W2417543344 hasAuthorship W2417543344A5062818514 @default.
- W2417543344 hasAuthorship W2417543344A5081651440 @default.
- W2417543344 hasAuthorship W2417543344A5086064402 @default.
- W2417543344 hasConcept C126322002 @default.
- W2417543344 hasConcept C164705383 @default.
- W2417543344 hasConcept C178853913 @default.
- W2417543344 hasConcept C26635844 @default.
- W2417543344 hasConcept C2777499176 @default.
- W2417543344 hasConcept C2778435403 @default.
- W2417543344 hasConcept C2778921608 @default.
- W2417543344 hasConcept C2779311647 @default.
- W2417543344 hasConcept C2779676291 @default.
- W2417543344 hasConcept C42219234 @default.
- W2417543344 hasConcept C500558357 @default.
- W2417543344 hasConcept C541997718 @default.
- W2417543344 hasConcept C71924100 @default.
- W2417543344 hasConceptScore W2417543344C126322002 @default.
- W2417543344 hasConceptScore W2417543344C164705383 @default.
- W2417543344 hasConceptScore W2417543344C178853913 @default.
- W2417543344 hasConceptScore W2417543344C26635844 @default.
- W2417543344 hasConceptScore W2417543344C2777499176 @default.
- W2417543344 hasConceptScore W2417543344C2778435403 @default.
- W2417543344 hasConceptScore W2417543344C2778921608 @default.
- W2417543344 hasConceptScore W2417543344C2779311647 @default.
- W2417543344 hasConceptScore W2417543344C2779676291 @default.
- W2417543344 hasConceptScore W2417543344C42219234 @default.
- W2417543344 hasConceptScore W2417543344C500558357 @default.
- W2417543344 hasConceptScore W2417543344C541997718 @default.
- W2417543344 hasConceptScore W2417543344C71924100 @default.
- W2417543344 hasIssue "3" @default.
- W2417543344 hasLocation W24175433441 @default.
- W2417543344 hasOpenAccess W2417543344 @default.
- W2417543344 hasPrimaryLocation W24175433441 @default.
- W2417543344 hasRelatedWork W1964690675 @default.
- W2417543344 hasRelatedWork W1976894351 @default.
- W2417543344 hasRelatedWork W1978054210 @default.
- W2417543344 hasRelatedWork W1980807541 @default.
- W2417543344 hasRelatedWork W2011303035 @default.
- W2417543344 hasRelatedWork W2016514413 @default.
- W2417543344 hasRelatedWork W2017343793 @default.
- W2417543344 hasRelatedWork W2038727826 @default.
- W2417543344 hasRelatedWork W2055237220 @default.
- W2417543344 hasRelatedWork W2061621535 @default.
- W2417543344 hasRelatedWork W2066766993 @default.
- W2417543344 hasRelatedWork W2091686578 @default.
- W2417543344 hasRelatedWork W2106394002 @default.
- W2417543344 hasRelatedWork W2154253285 @default.
- W2417543344 hasRelatedWork W2291409091 @default.
- W2417543344 hasRelatedWork W2373482758 @default.
- W2417543344 hasRelatedWork W2397524761 @default.
- W2417543344 hasRelatedWork W2411370180 @default.
- W2417543344 hasRelatedWork W3009199745 @default.
- W2417543344 hasRelatedWork W3145924875 @default.
- W2417543344 hasVolume "23" @default.
- W2417543344 isParatext "false" @default.
- W2417543344 isRetracted "false" @default.
- W2417543344 magId "2417543344" @default.
- W2417543344 workType "article" @default.