FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2417545413> ?p ?o ?g. }

• W2417545413 abstract "Background Patient global disease activity score (PGDA) in patients with rheumatoid arthritis (RA) represents the patient9s evaluation of disease and is included as one of four variables in the DAS28 score. Ultrasound (US) is a valid tool for assessing synovitis. However, there are no studies on how PGDA relates to US in patients with established RA during treatment. Objectives To explore the associations between PGDA and subjective as well as objective measures of disease activity, including US, during one year follow-up of RA patients starting biologic medication. Methods 213 patients (82% women, 80% anti-CCP positive, mean (SD) age 52.4 (13.4) years with 10.2 (8.6) years of disease duration) were included and assessed at baseline when starting biologic medication, and after 1, 2, 3, 6 and 12 months. PGDA was assessed on a 100mm visual analogue scale (VAS). US was performed of 36 joints (MCP 1-5, PIP 2-3, wrist (RC, IC, RU), elbow, knee, talo-crural, MTP 1-5 bilaterally) and 4 tendons (Ext. carpi ulnaris and Tib. post bilaterally), all scored 0-3 of grey scale (GS) and power Doppler (PD)) by one sonographer (HBH) (Siemens Antares), and the total sum scores of GS and PD from all joints/tendons were calculated. Patient reported outcomes (PROs) included pain VAS, the Rheumatoid Arthritis Impact of Disease (RAID) score (including questions on pain, functional capacity, fatigue, physical and emotional wellbeing, quality of sleep and coping) with calculation of total RAID score, modified HAQ (MHAQ), fatigue VAS, Hospital Anxiety and Depression Scale (HADS) with calculation of total sum scores. Patients scored their joint pain 0-3 in 36 joints on a figure, and sum scores were calculated. Two questions from the Coping Strategies Questionnaire were used for assessing catastrophizing, and mean scores were calculated and divided into quartiles. Clinical examinations were performed by a study nurse including Investigator9s global VAS and tender and swollen joints (28 DAS joints and bilateral ankles and MTP joints (evaluated united), i.e. 32 joints). The sonographer and study nurse had no access to each other9s assessments. Improvement during treatment was explored by paired sample t-test, associations across quartiles by ANOVA, and Pearson correlations were used for associations between PGDA and the PROs, clinical and US assessments. Results At one year follow-up, 153 patients (72%) were still on the same biologic medication, and for these patients PGDA, all PROs, clinical and US assessments improved significantly (p Conclusions In this cohort of established RA, PGDA was highly associated with catastrophizing as well as with subjective assessments of disease activity, but only weakly or not at all with objective measures including US. The present discrepancy of patient experience and US findings should be further explored in studies also including recent onset RA. Disclosure of Interest None declared" @default.
• W2417545413 created "2016-06-24" @default.
• W2417545413 creator A5027107889 @default.
• W2417545413 creator A5036970733 @default.
• W2417545413 date "2015-06-01" @default.
• W2417545413 modified "2023-09-27" @default.
• W2417545413 title "THU0099 Patient Global Disease Activity is Highly Associated with Pain and Patient Reported Outcomes, but not with Ultrasound Findings During one Year Treatment of Patients with Established RA Starting Biologic Medication" @default.
• W2417545413 doi "https://doi.org/10.1136/annrheumdis-2015-eular.1899" @default.
• W2417545413 hasPublicationYear "2015" @default.
• W2417545413 type Work @default.
• W2417545413 sameAs 2417545413 @default.
• W2417545413 citedByCount "0" @default.
• W2417545413 crossrefType "journal-article" @default.
• W2417545413 hasAuthorship W2417545413A5027107889 @default.
• W2417545413 hasAuthorship W2417545413A5036970733 @default.
• W2417545413 hasConcept C126322002 @default.
• W2417545413 hasConcept C14184104 @default.
• W2417545413 hasConcept C1862650 @default.
• W2417545413 hasConcept C2777575956 @default.
• W2417545413 hasConcept C2779244835 @default.
• W2417545413 hasConcept C71924100 @default.
• W2417545413 hasConceptScore W2417545413C126322002 @default.
• W2417545413 hasConceptScore W2417545413C14184104 @default.
• W2417545413 hasConceptScore W2417545413C1862650 @default.
• W2417545413 hasConceptScore W2417545413C2777575956 @default.
• W2417545413 hasConceptScore W2417545413C2779244835 @default.
• W2417545413 hasConceptScore W2417545413C71924100 @default.
• W2417545413 hasLocation W24175454131 @default.
• W2417545413 hasOpenAccess W2417545413 @default.
• W2417545413 hasPrimaryLocation W24175454131 @default.
• W2417545413 hasRelatedWork W1980770845 @default.
• W2417545413 hasRelatedWork W2225812518 @default.
• W2417545413 hasRelatedWork W2325625809 @default.
• W2417545413 hasRelatedWork W2334341408 @default.
• W2417545413 hasRelatedWork W2409582058 @default.
• W2417545413 hasRelatedWork W2411171753 @default.
• W2417545413 hasRelatedWork W2411575013 @default.
• W2417545413 hasRelatedWork W2501939219 @default.
• W2417545413 hasRelatedWork W2554905988 @default.
• W2417545413 hasRelatedWork W261574428 @default.
• W2417545413 hasRelatedWork W2625530172 @default.
• W2417545413 hasRelatedWork W2744603594 @default.
• W2417545413 hasRelatedWork W2754196864 @default.
• W2417545413 hasRelatedWork W2901468742 @default.
• W2417545413 hasRelatedWork W2901769468 @default.
• W2417545413 hasRelatedWork W2908834481 @default.
• W2417545413 hasRelatedWork W2908839200 @default.
• W2417545413 hasRelatedWork W3092632072 @default.
• W2417545413 hasRelatedWork W3164974427 @default.
• W2417545413 hasRelatedWork W9857653 @default.
• W2417545413 isParatext "false" @default.
• W2417545413 isRetracted "false" @default.
• W2417545413 magId "2417545413" @default.
• W2417545413 workType "article" @default.