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• W2417577215 abstract "Two experiments examined whether replacement therapy with recombinantly derived bovine somatotropin (rbST) would induce puberty in heifers that had been actively immunized at 6 mo of age against growth hormone-releasing factor (GRF). Heifers received daily i.m. injections of 25 mg of rbST (Exp. 1, n = 6; Exp. 2, n = 4) or vehicle (VEH; Exp. 1, n = 6; Exp. 2, n = 4) for 56 d. Serum concentrations of somatotropin (ST, nanograms/milliliter) were low in all heifers before first injection in Exp. 1 (1.56 ± .04) and 2 (.95 ± .03). During treatment, serum ST was greater (P <.01) in rbST than in VEH heifers (75.4 ± 4.8 vs 2.8 ± .1 ng/mL, respectively) in both experiments and remained increased through d 57 (32.2 ± 6.4 vs .90 ± .01 ng/mL). In Exp. 1 and 2, concentrations of serum IGF-I were similar in rbST and VEH heifers before treatment, increased (P <.01) 12 h after first rbST, and remained increased (P <.01) through d 57 in rbST heifers. Concentrations of serum insulin (INS) and plasma glucose (GLU) were similar (P > . 10) in rbST and VEH heifers before first injection (Exp. 1 and 2). Serum INS (micro-units/ milliliter) was greater (P <.01) in rbST (61.7 ± 3.7 and 36.0 ± 2.4) than in VEH (12.4 ± 1.6 and 8.1 ± 1.0) heifers on d 1 or 2 only, in Exp. 1 and 2, respectively. In Exp. 1, GLU was increased (P < .05) by rbST on d 2 through 57, but only on d 1 in Exp. 2. Proportion of heifers pubertal by d 21 tended to be greater (P <.07) in rbST (3 of 6) than in VEH (0 of 5) heifers in Exp. 1, but not in Exp. 2 ( 1 of 4 vs 1 of 4, respectively). All heifers in Exp. 1 and 50% of the heifers in Exp. 2 attained puberty by d 56. Daily rbST increased ST, IGF-I, INS, and GLU but did not hasten onset of puberty in heifers immunized against GRF" @default.
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• W2417577215 date "1994-07-01" @default.
• W2417577215 modified "2023-10-18" @default.
• W2417577215 title "Effect of daily replacement therapy with recombinant bovine somatotropin on somatotropin, insulin-like growth factor I, and onset of puberty in beef heifers immunized against growth hormone-releasing factor" @default.
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• W2417577215 doi "https://doi.org/10.2527/1994.7271786x" @default.
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