Matches in SemOpenAlex for { <https://semopenalex.org/work/W2417657560> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2417657560 endingPage "13" @default.
- W2417657560 startingPage "201" @default.
- W2417657560 abstract "The effects of 5-methoxypsoralen (5-MOP) on the distribution and metabolism of chemical carcinogens such as 2-aminofluorene (AF) has not been previously reported. In this study, the influences of 5-MOP on the metabolism of AF in Sprague-Dawley (SD) rats were investigated.After receiving 5-MOP in 24 hours, AF was introduced into each animal by gastric intubation. After 12, 24, 48 and 72 hours the urine, feces, and cytosol of the liver, kidneys, stomach, colon, bladder and blood of rats were collected and assayed for AF and its metabolites by HPLC.Compared to the control regimen, 5-MOP caused an increase of the metabolites excreted in urine and feces. The largest dose of metabolites were excreted between 48-72 hours. The major metabolite excreted in the urine was 9-hydroxy-AAF (9-OH-AAF) and in the feces was 7-hydroxy-AAF (7-OH-AAF). There was no time-effect for the tissues, and the liver was the main target organ for the AF and its metabolites. The major residual metabolite of AF in the liver, kidneys, stomach, colon and bladder was 7-OH-AAF. In blood it was 9-OH-AAF. The bladder had the lowest metabolic residue in tissues, and blood played the role of transportation but was not the target organ. 5-MOP decreased the concentration of AF and its residual metabolites of liver, stomach, kidneys, bladder and blood at various times.5-MOP increased the metabolism of AF in order to transform to ring-hydroxylated metabolites and increased excretion of the ring-hydroxylated metabolites, therefore decreasing AF and its residual metabolites in vivo. Although 5-MOP was shown to be an inhibitor of CYP 2A6 and CYP 2B1, somehow it causes an increase of activity in AF metabolism in vivo; it induces more CYPs involved in the metabolism of AF." @default.
- W2417657560 created "2016-06-24" @default.
- W2417657560 creator A5037116428 @default.
- W2417657560 creator A5049214477 @default.
- W2417657560 creator A5050670539 @default.
- W2417657560 creator A5085136080 @default.
- W2417657560 creator A5087091914 @default.
- W2417657560 date "2002-08-17" @default.
- W2417657560 modified "2023-09-26" @default.
- W2417657560 title "Oral administration of 5-methoxypsoralen affects the distribution and metabolism of 2-aminofluorene in Sprague-Dawley rats." @default.
- W2417657560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12182117" @default.
- W2417657560 hasPublicationYear "2002" @default.
- W2417657560 type Work @default.
- W2417657560 sameAs 2417657560 @default.
- W2417657560 citedByCount "3" @default.
- W2417657560 crossrefType "journal-article" @default.
- W2417657560 hasAuthorship W2417657560A5037116428 @default.
- W2417657560 hasAuthorship W2417657560A5049214477 @default.
- W2417657560 hasAuthorship W2417657560A5050670539 @default.
- W2417657560 hasAuthorship W2417657560A5085136080 @default.
- W2417657560 hasAuthorship W2417657560A5087091914 @default.
- W2417657560 hasConcept C114246631 @default.
- W2417657560 hasConcept C126322002 @default.
- W2417657560 hasConcept C134018914 @default.
- W2417657560 hasConcept C151730666 @default.
- W2417657560 hasConcept C185592680 @default.
- W2417657560 hasConcept C2777056448 @default.
- W2417657560 hasConcept C2777477808 @default.
- W2417657560 hasConcept C2779422922 @default.
- W2417657560 hasConcept C2780026642 @default.
- W2417657560 hasConcept C55493867 @default.
- W2417657560 hasConcept C61716771 @default.
- W2417657560 hasConcept C62231903 @default.
- W2417657560 hasConcept C71924100 @default.
- W2417657560 hasConcept C86803240 @default.
- W2417657560 hasConcept C98274493 @default.
- W2417657560 hasConceptScore W2417657560C114246631 @default.
- W2417657560 hasConceptScore W2417657560C126322002 @default.
- W2417657560 hasConceptScore W2417657560C134018914 @default.
- W2417657560 hasConceptScore W2417657560C151730666 @default.
- W2417657560 hasConceptScore W2417657560C185592680 @default.
- W2417657560 hasConceptScore W2417657560C2777056448 @default.
- W2417657560 hasConceptScore W2417657560C2777477808 @default.
- W2417657560 hasConceptScore W2417657560C2779422922 @default.
- W2417657560 hasConceptScore W2417657560C2780026642 @default.
- W2417657560 hasConceptScore W2417657560C55493867 @default.
- W2417657560 hasConceptScore W2417657560C61716771 @default.
- W2417657560 hasConceptScore W2417657560C62231903 @default.
- W2417657560 hasConceptScore W2417657560C71924100 @default.
- W2417657560 hasConceptScore W2417657560C86803240 @default.
- W2417657560 hasConceptScore W2417657560C98274493 @default.
- W2417657560 hasIssue "3" @default.
- W2417657560 hasLocation W24176575601 @default.
- W2417657560 hasOpenAccess W2417657560 @default.
- W2417657560 hasPrimaryLocation W24176575601 @default.
- W2417657560 hasRelatedWork W2026510834 @default.
- W2417657560 hasRelatedWork W2045937169 @default.
- W2417657560 hasRelatedWork W2087008860 @default.
- W2417657560 hasRelatedWork W2145270223 @default.
- W2417657560 hasRelatedWork W2154910834 @default.
- W2417657560 hasRelatedWork W2284081933 @default.
- W2417657560 hasRelatedWork W2409170744 @default.
- W2417657560 hasRelatedWork W2409773942 @default.
- W2417657560 hasRelatedWork W2414148092 @default.
- W2417657560 hasRelatedWork W2417657560 @default.
- W2417657560 hasVolume "16" @default.
- W2417657560 isParatext "false" @default.
- W2417657560 isRetracted "false" @default.
- W2417657560 magId "2417657560" @default.
- W2417657560 workType "article" @default.