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- W2417776112 abstract "Early post-burn ischemic necrosis of the skin is of particular interest in modern burn research. The purpose of this study was to test the hypothesis that blood perfusion could be improved by the topical application of vasoactive substances. A sample of 55 wistar rats was used to investigate the effect of 0,4% nitroglycerin ointment (Rectogesic(®)) comparatively to no application and placebo. The beneficiary action of 5% prilocaine/lidocaine cream (EMLA(®)) in burn blood perfusion was also tested comparatively to Rectogesic(®). Both preparations were tested respectively to non burned controls. Laser Doppler assessment of blood flow at 15, 30, 45, 60, 120 and 180 minutes after preparation application, demonstrated that the use of Rectogesic(®) improved perfusion at all measurements compared to placebo and to no preparation application (p&0,05). There was no statistical significant difference in the effect of the two preparations. La nécrose ischémique précoce de la peau brûlée est d’un grand intérêt dans la recherche actuelle en brûlologie. Le but de cette étude était de vérifier l’hypothèse que la vascularisation peut être améliorée par l’application topique de substances vaso-actives. Un échantillon de 55 rats Wistar a été utilisé pour étudier l’effet de 0,4% onguent à la nitroglycérine (Rectogesic®) comparativement à aucune application d’onguent et un placebo. L’action bénéfique de la crème lidocaïne (EMLA®)( 5% prilocaïne) sur la vascularisation cutanée a également été testé comparativement àvec le Rectogesic®. Les deux préparations ont été testées respectivement sur des témoins non brûlés. Une évaluation Laser Doppler du flux sanguin à 15, 30, 45, 60, 120 et 180 minutes après l’application de la préparation, a démontré que l’utilisation de Rectogesic® améliore la circulation à chaque mesure par rapport au placebo et par rapport à la non application d’onguent (p&0,05). Il n’y avait aucune différence statistiquement significative dans l’incidence des deux préparations." @default.
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- W2417776112 date "2015-06-30" @default.
- W2417776112 modified "2023-09-26" @default.
- W2417776112 title "Topical use of Rectogesic® and Emla® to improve cutaneous blood perfusion following thermal injury. A comparative experimental study." @default.
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