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- W2417822906 abstract "Tricyclic antidepressant plasma levels were measured in patients and healthy subjects after a single dise of desmethylimipramine (DMI) or imipramine (IMI) and after chronic dosing to steady states. Tricyclic plasma levels measured 24 hr after the single oral dose correlated with steady-state plasma levels. In patients receiving DMI there was a correlation (r = 0.97, n = 10) between 24-hr and steady-state DMI levels, while in normal subjects receiving IMI the correlation was r = 0.92 (n = 20) between 24-hr and steady-state total tricyclic levels (IMI plus its metabolite, DMI). These results suggest the possibility that after a test dose of tricyclic antidepressant, a patient may be put on a therapeutic dosage regimen without delay." @default.
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- W2417822906 date "1979-05-01" @default.
- W2417822906 modified "2023-10-18" @default.
- W2417822906 title "Prediction of steady-state imipramine and desmethylimipramine plasma concentrations from single-dose data" @default.
- W2417822906 doi "https://doi.org/10.1002/cpt1979255part1605" @default.
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