FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2417825232> ?p ?o ?g. }

• W2417825232 endingPage "83" @default.
• W2417825232 startingPage "71" @default.
• W2417825232 abstract "Since the publication of the World Health Organization blue book in 2004, several recent studies have provided new insights on the pathologic aspects of urachal neoplasms. The proposed updates include modified criteria for the diagnosis of urachal carcinoma. A uniform nomenclature for cystic tumors was lacking, and it is recommended that urachal mucinous cystic tumors should be separated and classified in a manner similar to ovarian mucinous neoplasms. The spectrum includes mucinous cystadenoma, mucinous cystic tumor of low malignant potential, mucinous cystic tumor of low malignant potential with intraepithelial carcinoma, and microscopically or frankly invasive mucinous cystadenocarcinoma, with 65% of cystic tumors classified as mucinous cystic tumor of low malignant potential. Most importantly, it has been shown that progression-free survival of noninvasive mucinous cystic tumors is significantly better than noncystic invasive adenocarcinoma. This development, along with prior descriptions of urachal villous adenoma, has also reaffirmed the occurrence of benign tumors of urachal epithelial origin. For noncystic (usual) invasive adenocarcinomas, the traditionally described histologic subtypes of enteric, mucinous, signet ring cell, not otherwise specified, and mixed remain appropriate, with 50% of tumors classified as mucinous subtype. Although this subtyping is helpful in diagnosis and differential diagnosis, the clinical significance of subtyping adenocarcinoma is still uncertain. Rare nonglandular morphologies such as urothelial, squamous, and neuroendocrine carcinoma in urachal carcinomas have been described in detail with proposals for their own set of diagnostic criteria. These criteria are based on unique features of urachal nonglandular carcinomas. Among the immunomarkers studied, only β-catenin and CK7 may be of help in the distinction of urachal from colorectal adenocarcinoma. Awareness of the expression profile of immunomarkers such as CDX2, P504S (racemase), PSMA, claudin-18, and REG IV in urachal tumors and in tumors in the differential diagnosis is important to avoid overreliance of these markers in the diagnosis. Limited studies have identified KRAS mutations interestingly only in mucinous adenocarcinoma and exclusive of MSI loss, and mutations in BRAF are not present. Several alternative tumor staging approaches (eg, Mayo, Ontario, TNM systems) different from the traditional staging proposed by Sheldon are used that provide better tumor distribution across stages; however, the prognostic utility of the stage substratification has yet to be validated in large prospective studies. Evidence though suggests that staging urachal cancer is most pertinent when dichotomized to tumors that have spread outside versus within the perivesical tissue. Only high tumor stage and residual tumor after surgery have been shown to be independent predictors of outcome. This review updates the contemporary classification of urachal epithelial tumors, which has informed the upcoming 2016 classification of World Health Organization tumors. We provide modified criteria for diagnosing urachal adenocarcinomas, which remains a clinico-pathologic exercise. The role of ancillary diagnostic methodology and issues pertaining to staging and prognostication are presented." @default.
• W2417825232 created "2016-06-24" @default.
• W2417825232 creator A5043709533 @default.
• W2417825232 creator A5044996624 @default.
• W2417825232 creator A5052263885 @default.
• W2417825232 creator A5058161742 @default.
• W2417825232 date "2016-03-01" @default.
• W2417825232 modified "2023-10-03" @default.
• W2417825232 title "Updates in the Pathologic Diagnosis and Classification of Epithelial Neoplasms of Urachal Origin" @default.
• W2417825232 cites W103386265 @default.
• W2417825232 cites W113790134 @default.
• W2417825232 cites W1151143637 @default.
• W2417825232 cites W1497767576 @default.
• W2417825232 cites W1534435740 @default.
• W2417825232 cites W1539676776 @default.
• W2417825232 cites W1603896201 @default.
• W2417825232 cites W1971696356 @default.
• W2417825232 cites W1973345553 @default.
• W2417825232 cites W1978208336 @default.
• W2417825232 cites W1981615876 @default.
• W2417825232 cites W1991724283 @default.
• W2417825232 cites W1992790404 @default.
• W2417825232 cites W1995538445 @default.
• W2417825232 cites W1995611924 @default.
• W2417825232 cites W1998223857 @default.
• W2417825232 cites W1999461312 @default.
• W2417825232 cites W1999783967 @default.
• W2417825232 cites W2000875720 @default.
• W2417825232 cites W2004661132 @default.
• W2417825232 cites W2005885226 @default.
• W2417825232 cites W2006903895 @default.
• W2417825232 cites W2008087900 @default.
• W2417825232 cites W2011556797 @default.
• W2417825232 cites W2012009298 @default.
• W2417825232 cites W2012193024 @default.
• W2417825232 cites W2015637963 @default.
• W2417825232 cites W2024085953 @default.
• W2417825232 cites W2031750048 @default.
• W2417825232 cites W2032454374 @default.
• W2417825232 cites W2035304803 @default.
• W2417825232 cites W2040972541 @default.
• W2417825232 cites W2042204376 @default.
• W2417825232 cites W2042261243 @default.
• W2417825232 cites W2045751711 @default.
• W2417825232 cites W2047751263 @default.
• W2417825232 cites W2053066993 @default.
• W2417825232 cites W2057117979 @default.
• W2417825232 cites W2057608657 @default.
• W2417825232 cites W2061321479 @default.
• W2417825232 cites W2065628014 @default.
• W2417825232 cites W2065851629 @default.
• W2417825232 cites W2074884346 @default.
• W2417825232 cites W2075121084 @default.
• W2417825232 cites W2080575375 @default.
• W2417825232 cites W2081280400 @default.
• W2417825232 cites W2084586632 @default.
• W2417825232 cites W2087770330 @default.
• W2417825232 cites W2092871423 @default.
• W2417825232 cites W2109242194 @default.
• W2417825232 cites W2114005284 @default.
• W2417825232 cites W2128412483 @default.
• W2417825232 cites W2132306767 @default.
• W2417825232 cites W2140111302 @default.
• W2417825232 cites W2146132935 @default.
• W2417825232 cites W2150174223 @default.
• W2417825232 cites W2153308941 @default.
• W2417825232 cites W2157670918 @default.
• W2417825232 cites W2158558471 @default.
• W2417825232 cites W2161331723 @default.
• W2417825232 cites W2318080942 @default.
• W2417825232 cites W2325526750 @default.
• W2417825232 cites W2327495162 @default.
• W2417825232 cites W2332666374 @default.
• W2417825232 cites W2335966374 @default.
• W2417825232 cites W2429378860 @default.
• W2417825232 cites W2432060050 @default.
• W2417825232 cites W2435357585 @default.
• W2417825232 cites W2727123785 @default.
• W2417825232 cites W3142355744 @default.
• W2417825232 cites W4239892251 @default.
• W2417825232 cites W93152694 @default.
• W2417825232 cites W99110273 @default.
• W2417825232 doi "https://doi.org/10.1097/pap.0000000000000110" @default.
• W2417825232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26849813" @default.
• W2417825232 hasPublicationYear "2016" @default.
• W2417825232 type Work @default.
• W2417825232 sameAs 2417825232 @default.
• W2417825232 citedByCount "62" @default.
• W2417825232 countsByYear W24178252322016 @default.
• W2417825232 countsByYear W24178252322017 @default.
• W2417825232 countsByYear W24178252322018 @default.
• W2417825232 countsByYear W24178252322019 @default.
• W2417825232 countsByYear W24178252322020 @default.
• W2417825232 countsByYear W24178252322021 @default.
• W2417825232 countsByYear W24178252322022 @default.
• W2417825232 countsByYear W24178252322023 @default.
• W2417825232 crossrefType "journal-article" @default.
• W2417825232 hasAuthorship W2417825232A5043709533 @default.

• next