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• W2417846945 endingPage "2079" @default.
• W2417846945 startingPage "2064" @default.
• W2417846945 abstract "Coordinated membrane and cytoskeletal remodeling activities are required for membrane extension in processes such as cytokinesis and syncytial nuclear division cycles in Drosophila. Pseudocleavage furrow membranes in the syncytial Drosophila blastoderm embryo show rapid extension and retraction regulated by actin-remodeling proteins. The F-BAR domain protein Syndapin (Synd) is involved in membrane tubulation, endocytosis, and, uniquely, in F-actin stability. Here we report a role for Synd in actin-regulated pseudocleavage furrow formation. Synd localized to these furrows, and its loss resulted in short, disorganized furrows. Synd presence was important for the recruitment of the septin Peanut and distribution of Diaphanous and F-actin at furrows. Synd and Peanut were both absent in furrow-initiation mutants of RhoGEF2 and Diaphanous and in furrow-progression mutants of Anillin. Synd overexpression in rhogef2 mutants reversed its furrow-extension phenotypes, Peanut and Diaphanous recruitment, and F-actin organization. We conclude that Synd plays an important role in pseudocleavage furrow extension, and this role is also likely to be crucial in cleavage furrow formation during cell division." @default.
• W2417846945 created "2016-06-24" @default.
• W2417846945 creator A5002420782 @default.
• W2417846945 creator A5048116805 @default.
• W2417846945 date "2016-07-01" @default.
• W2417846945 modified "2023-10-14" @default.
• W2417846945 title "Syndapin promotes pseudocleavage furrow formation by actin organization in the syncytial<i>Drosophila</i>embryo" @default.
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