FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2417868067> ?p ?o ?g. }

• W2417868067 endingPage "6448" @default.
• W2417868067 startingPage "6437" @default.
• W2417868067 abstract "Metastatic progression of tumors requires the coordinated dissemination of cancerous cells through interstitial tissues and their replication in distant body locations. Despite their importance in cancer treatment decisions, key factors, such as cell shape adaptation and the role it plays in dense tissue invasion by cancerous cells, are not well understood. Here, we employ a 3D electrohydrodynamic nanoprinting technology to generate vertical arrays of topographical pores that mimic interstitial tissue resistance to the mesenchymal migration of cancerous cells, in order to determine the effect of nuclear size, cell deformability, and cell-to-substrate adhesion on tissue invasion efficiency. The high spatial and temporal resolution of our analysis demonstrates that the ability of cells to deform depends on the cell cycle phase, peaks immediately after mitosis, and is key to the invasion process. Increased pore penetration efficiency by cells in early G1 phase also coincided with their lower nuclear volume and higher cell deformability, compared with the later cell cycle stages. Furthermore, artificial decondensation of chromatin induced an increase in cell and nuclear deformability and improved pore penetration efficiency of cells in G1. Together, these results underline that along the cell cycle cells have different abilities to dynamically remodel their actin cytoskeleton and induce nuclear shape changes, which determines their pore penetration efficiency. Thus, our results support a mechanism in which cell proliferation and pore penetration are functionally linked to favor the interstitial dissemination of metastatic cells." @default.
• W2417868067 created "2016-06-24" @default.
• W2417868067 creator A5013514374 @default.
• W2417868067 creator A5024731714 @default.
• W2417868067 creator A5033475302 @default.
• W2417868067 creator A5034966136 @default.
• W2417868067 creator A5067823651 @default.
• W2417868067 creator A5074435194 @default.
• W2417868067 date "2016-06-10" @default.
• W2417868067 modified "2023-10-18" @default.
• W2417868067 title "A Nanoprinted Model of Interstitial Cancer Migration Reveals a Link between Cell Deformability and Proliferation" @default.
• W2417868067 cites W1520425169 @default.
• W2417868067 cites W1590619267 @default.
• W2417868067 cites W1808025966 @default.
• W2417868067 cites W1964292350 @default.
• W2417868067 cites W1972170345 @default.
• W2417868067 cites W1975600663 @default.
• W2417868067 cites W1989197126 @default.
• W2417868067 cites W1991370659 @default.
• W2417868067 cites W1996435746 @default.
• W2417868067 cites W2005309418 @default.
• W2417868067 cites W2006543111 @default.
• W2417868067 cites W2015989042 @default.
• W2417868067 cites W2019922483 @default.
• W2417868067 cites W2023560061 @default.
• W2417868067 cites W2035538295 @default.
• W2417868067 cites W2036631612 @default.
• W2417868067 cites W2039767921 @default.
• W2417868067 cites W204442321 @default.
• W2417868067 cites W2056002615 @default.
• W2417868067 cites W2057621066 @default.
• W2417868067 cites W2065886242 @default.
• W2417868067 cites W2071206866 @default.
• W2417868067 cites W2071418499 @default.
• W2417868067 cites W2080232352 @default.
• W2417868067 cites W2089485530 @default.
• W2417868067 cites W2090687743 @default.
• W2417868067 cites W2091817614 @default.
• W2417868067 cites W2105002450 @default.
• W2417868067 cites W2110344693 @default.
• W2417868067 cites W2112401372 @default.
• W2417868067 cites W2114917071 @default.
• W2417868067 cites W2116269551 @default.
• W2417868067 cites W2117954572 @default.
• W2417868067 cites W2122867798 @default.
• W2417868067 cites W2123582615 @default.
• W2417868067 cites W2126845517 @default.
• W2417868067 cites W2129926378 @default.
• W2417868067 cites W2130284011 @default.
• W2417868067 cites W2133054656 @default.
• W2417868067 cites W2139276645 @default.
• W2417868067 cites W2140991469 @default.
• W2417868067 cites W2150895717 @default.
• W2417868067 cites W2154026141 @default.
• W2417868067 cites W2161983416 @default.
• W2417868067 cites W2172002964 @default.
• W2417868067 cites W2172240370 @default.
• W2417868067 cites W2189501942 @default.
• W2417868067 cites W2277592932 @default.
• W2417868067 cites W4246707411 @default.
• W2417868067 doi "https://doi.org/10.1021/acsnano.5b07406" @default.
• W2417868067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27268411" @default.
• W2417868067 hasPublicationYear "2016" @default.
• W2417868067 type Work @default.
• W2417868067 sameAs 2417868067 @default.
• W2417868067 citedByCount "32" @default.
• W2417868067 countsByYear W24178680672016 @default.
• W2417868067 countsByYear W24178680672017 @default.
• W2417868067 countsByYear W24178680672018 @default.
• W2417868067 countsByYear W24178680672019 @default.
• W2417868067 countsByYear W24178680672020 @default.
• W2417868067 countsByYear W24178680672021 @default.
• W2417868067 countsByYear W24178680672022 @default.
• W2417868067 countsByYear W24178680672023 @default.
• W2417868067 crossrefType "journal-article" @default.
• W2417868067 hasAuthorship W2417868067A5013514374 @default.
• W2417868067 hasAuthorship W2417868067A5024731714 @default.
• W2417868067 hasAuthorship W2417868067A5033475302 @default.
• W2417868067 hasAuthorship W2417868067A5034966136 @default.
• W2417868067 hasAuthorship W2417868067A5067823651 @default.
• W2417868067 hasAuthorship W2417868067A5074435194 @default.
• W2417868067 hasConcept C121608353 @default.
• W2417868067 hasConcept C12554922 @default.
• W2417868067 hasConcept C1491633281 @default.
• W2417868067 hasConcept C192562407 @default.
• W2417868067 hasConcept C29537977 @default.
• W2417868067 hasConcept C54355233 @default.
• W2417868067 hasConcept C55493867 @default.
• W2417868067 hasConcept C62112901 @default.
• W2417868067 hasConcept C86803240 @default.
• W2417868067 hasConcept C93304396 @default.
• W2417868067 hasConcept C95444343 @default.
• W2417868067 hasConcept C96232424 @default.
• W2417868067 hasConceptScore W2417868067C121608353 @default.
• W2417868067 hasConceptScore W2417868067C12554922 @default.
• W2417868067 hasConceptScore W2417868067C1491633281 @default.
• W2417868067 hasConceptScore W2417868067C192562407 @default.
• W2417868067 hasConceptScore W2417868067C29537977 @default.

• next