FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2417961114> ?p ?o ?g. }

• W2417961114 endingPage "24" @default.
• W2417961114 startingPage "20" @default.
• W2417961114 abstract "Recent studies have shown that astrocytes play important roles in ATP degradation and adenosine (a well known analgesic molecule) generation, which are closely related to pain signaling pathway. The aim of this study was to investigate whether morphine, a well known analgesic drug, could affect the speeds of ATP enzymolysis and adenosine generation in rat astrocytes. Intracellular calcium concentration ([Ca(2+)](i)) of astrocyte was measured by flow cytometry, and the time points that morphine exerted notable effects were determined for subsequent experiments. Cultured astrocytes were pre-incubated with morphine (1 μmol/L) and then were incubated with substrates, ATP and AMP, for 30 min. The speeds of ATP enzymolysis and adenosine generation were measured by high performance liquid chromatography (HPLC). The results showed that both 1.5 and 48 h of morphine pre-incubation induced maximal ATP enzymolysis speed in astrocytes among all the time points, and there was no statistical difference of ATP enzymolysis speed between morphine treatments for 1.5 and 48 h. As to adenosine, morphine pre-incubation for 1.5 h statistically increased adenosine generation, which was degraded from AMP, in cultured astrocytes compared with control group. However, no difference of adenosine generation was observed after 48 h of morphine pre-incubation. These results indicate that treatment of morphine in vitro dynamically changes the concentrations of ATP and adenosine in extracellular milieu of astrocytic cells. In addition, astrocyte can be regarded as at least one of the target cells of morphine to induce changes of ATP and adenosine levels in central nervous system." @default.
• W2417961114 created "2016-06-24" @default.
• W2417961114 creator A5016118186 @default.
• W2417961114 creator A5019587287 @default.
• W2417961114 creator A5021022471 @default.
• W2417961114 creator A5034042779 @default.
• W2417961114 creator A5048145081 @default.
• W2417961114 creator A5062828907 @default.
• W2417961114 creator A5075091950 @default.
• W2417961114 creator A5084521040 @default.
• W2417961114 date "2011-02-25" @default.
• W2417961114 modified "2023-09-24" @default.
• W2417961114 title "Morphine treatment enhances extracellular ATP enzymolysis and adenosine generation in rat astrocytes." @default.
• W2417961114 cites W1936310758 @default.
• W2417961114 cites W1950988695 @default.
• W2417961114 cites W1969761928 @default.
• W2417961114 cites W1984025105 @default.
• W2417961114 cites W1998475926 @default.
• W2417961114 cites W2008039066 @default.
• W2417961114 cites W2014285566 @default.
• W2417961114 cites W2020468817 @default.
• W2417961114 cites W2042698939 @default.
• W2417961114 cites W2059994807 @default.
• W2417961114 cites W2065686546 @default.
• W2417961114 cites W2065854120 @default.
• W2417961114 cites W2088291447 @default.
• W2417961114 cites W2095213066 @default.
• W2417961114 cites W2107633966 @default.
• W2417961114 cites W2116863239 @default.
• W2417961114 cites W2142899898 @default.
• W2417961114 cites W2286208764 @default.
• W2417961114 cites W2350599581 @default.
• W2417961114 cites W2421236103 @default.
• W2417961114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21340430" @default.
• W2417961114 hasPublicationYear "2011" @default.
• W2417961114 type Work @default.
• W2417961114 sameAs 2417961114 @default.
• W2417961114 citedByCount "2" @default.
• W2417961114 countsByYear W24179611142012 @default.
• W2417961114 countsByYear W24179611142017 @default.
• W2417961114 crossrefType "journal-article" @default.
• W2417961114 hasAuthorship W2417961114A5016118186 @default.
• W2417961114 hasAuthorship W2417961114A5019587287 @default.
• W2417961114 hasAuthorship W2417961114A5021022471 @default.
• W2417961114 hasAuthorship W2417961114A5034042779 @default.
• W2417961114 hasAuthorship W2417961114A5048145081 @default.
• W2417961114 hasAuthorship W2417961114A5062828907 @default.
• W2417961114 hasAuthorship W2417961114A5075091950 @default.
• W2417961114 hasAuthorship W2417961114A5084521040 @default.
• W2417961114 hasConcept C134018914 @default.
• W2417961114 hasConcept C185592680 @default.
• W2417961114 hasConcept C25642318 @default.
• W2417961114 hasConcept C2776991684 @default.
• W2417961114 hasConcept C2777389121 @default.
• W2417961114 hasConcept C2777542381 @default.
• W2417961114 hasConcept C2779564974 @default.
• W2417961114 hasConcept C28406088 @default.
• W2417961114 hasConcept C529278444 @default.
• W2417961114 hasConcept C55493867 @default.
• W2417961114 hasConcept C79879829 @default.
• W2417961114 hasConcept C86803240 @default.
• W2417961114 hasConcept C98274493 @default.
• W2417961114 hasConceptScore W2417961114C134018914 @default.
• W2417961114 hasConceptScore W2417961114C185592680 @default.
• W2417961114 hasConceptScore W2417961114C25642318 @default.
• W2417961114 hasConceptScore W2417961114C2776991684 @default.
• W2417961114 hasConceptScore W2417961114C2777389121 @default.
• W2417961114 hasConceptScore W2417961114C2777542381 @default.
• W2417961114 hasConceptScore W2417961114C2779564974 @default.
• W2417961114 hasConceptScore W2417961114C28406088 @default.
• W2417961114 hasConceptScore W2417961114C529278444 @default.
• W2417961114 hasConceptScore W2417961114C55493867 @default.
• W2417961114 hasConceptScore W2417961114C79879829 @default.
• W2417961114 hasConceptScore W2417961114C86803240 @default.
• W2417961114 hasConceptScore W2417961114C98274493 @default.
• W2417961114 hasIssue "1" @default.
• W2417961114 hasLocation W24179611141 @default.
• W2417961114 hasLocation W24179611142 @default.
• W2417961114 hasOpenAccess W2417961114 @default.
• W2417961114 hasPrimaryLocation W24179611141 @default.
• W2417961114 hasRelatedWork W1837803632 @default.
• W2417961114 hasRelatedWork W1966691812 @default.
• W2417961114 hasRelatedWork W1974409349 @default.
• W2417961114 hasRelatedWork W1989944353 @default.
• W2417961114 hasRelatedWork W2019762265 @default.
• W2417961114 hasRelatedWork W2027685264 @default.
• W2417961114 hasRelatedWork W2037874879 @default.
• W2417961114 hasRelatedWork W2046814702 @default.
• W2417961114 hasRelatedWork W2063928414 @default.
• W2417961114 hasRelatedWork W2084470637 @default.
• W2417961114 hasRelatedWork W2092544119 @default.
• W2417961114 hasRelatedWork W2093726219 @default.
• W2417961114 hasRelatedWork W2131664490 @default.
• W2417961114 hasRelatedWork W2153810291 @default.
• W2417961114 hasRelatedWork W2332912502 @default.
• W2417961114 hasRelatedWork W2369574379 @default.
• W2417961114 hasRelatedWork W2374419347 @default.
• W2417961114 hasRelatedWork W2601748428 @default.

• next