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- W2417962262 abstract "Hard capsules-filling machines are useful for measuring small quantities of powder in pharmacies and drug production for clinical research. In addition, they can be used as a teaching device during students' laboratory works. However, in literature, we could not find a method how to calculate the right quantity of powder needed to fill capsules; therefore, the experimental work with acetylsalicylic acid, paracetamol, and lactose was performed. Based on experimental work, a methodology for filling hard capsules with powder mixtures was developed. During experimental work, the influence of powder moisture and cohesiveness, filling conditions, and powder particle size on hard capsules filling was assessed. The dependency of capsules position in the machine on capsules filling was investigated. To confirm a reliability of the method three series of acetylsalicylic acid capsules were produced. The tests for uniformity of content and mass were performed. The applied methods of analysis confirmed that the uniformity of mass and content of produced capsules complied the requirements of European pharmacopoeia." @default.
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- W2417962262 date "2006-01-01" @default.
- W2417962262 modified "2023-09-23" @default.
- W2417962262 title "The development and evaluation of technology of hard capsules filling with powder mixtures" @default.
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