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- W2417962581 abstract "Abstract 1.1. Leukocyte removal was accomplished in rats by replacement transfusion of normal, splenectomized, and leukemic animals by normal rat blood rendered leukopenic by mechanical removal of leukocytes. 2.2. The normal rat mobilized leukocytes rapidly, so that severe leukopenia did not develop during the period of replacement transfusion and recovery to normal leukocyte levels occurred within 30 minutes. 3.3. Splenectomized rats, whether splenectomy was performed immediately before or 3 to 5 days before replacement transfusion, did not mobilize leukocytes as rapidly as the normal animal. It was evident that these animals had available leukocyte stores, however, since severe leukopenia was not induced. 4.4. Rats with Shay granulocytic chloroleukemia also had available leukocyte reserves, but marked decrease in leukocyte count was obtained by replacement transfusion. It was evident that the available leukocyte reserves in these animals were not increased in proportion to the circulating leukocyte level. 5.5. In all experiments the leukocytes mobilized as a result of sudden leukocyte removal were mature and of the same cell type as in the circulation of the animals. This suggested that the leukocyte reserves of the rat consist of a premixed population of granulocytes and lymphocytes, rather than individual granulocytic and lymphocytic storage depots. 6.6. It was suggested that the immediately available leukocyte reserves of the rat consist of both granulocytes and lymphocytes stored within vascular channels and that the splenic vascular bed constitutes only one portion of that leukocyte pool." @default.
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- W2417962581 date "1957-07-01" @default.
- W2417962581 modified "2023-09-23" @default.
- W2417962581 title "Leukocyte mobilization in normal, splenectomized, and leukemic rats after replacement transfusion." @default.
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