FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2417996629> ?p ?o ?g. }

• W2417996629 endingPage "671" @default.
• W2417996629 startingPage "667" @default.
• W2417996629 abstract "Summary In a group of 6 patients with lupus anticoagulant (LA) and antiphospholipid (aPL) antibodies detected by ELISA ovemight urine and blood were simultaneously collected. A significantly increased urinary excretion of the platelet-derived thromboxane (TX) metabolite 11-dehydro-TXB2 was found in this group, as compared to 12 healthy individuals. In contrast, a small but significant reduction of the vascular prostacyclin (PGI2) metabolite 2,3-dinor-6-keto-prostaglandin F1α was observed. To further elucidate the effect of these antibodies on platelet activation we isolated the F(ab’)2 fragments from IgG of the 6 patients and 5 Controls, and we evaluated the effect of these fragments on the responses of isolated normal platelets to thrombin. Patients’ F(ab’)2 increased platelet aggregation and serotonin release of platelets stimulated by low dose thrombin (0.01 U/ml). At threshold thrombin concentration (0.05 U/ml) an enhanced TXB2 production was also observed. In summary, our results show, in addition to the altered TXA2/PGI2 balance observed in vivo, a direct stimulatory effect of aPL antibodies on platelet activation in vitro. This effect is related to recognition of phospholipid epitopes on platelets as shown by its neutralization upon preincubation with phospholipids. This phenomenon may be relevant for the thrombotic tendency of these patients." @default.
• W2417996629 created "2016-06-24" @default.
• W2417996629 creator A5015334198 @default.
• W2417996629 creator A5042096585 @default.
• W2417996629 creator A5088588580 @default.
• W2417996629 creator A5091290798 @default.
• W2417996629 date "1993-01-01" @default.
• W2417996629 modified "2023-10-17" @default.
• W2417996629 title "Antiphospholipid Antibodies Enhance Thrombin-Induced Platelet Activation and Thromboxane Formation" @default.
• W2417996629 cites W1526209671 @default.
• W2417996629 cites W1594546643 @default.
• W2417996629 cites W1967602919 @default.
• W2417996629 cites W1974936177 @default.
• W2417996629 cites W1978533451 @default.
• W2417996629 cites W1987178686 @default.
• W2417996629 cites W2000055469 @default.
• W2417996629 cites W2007361354 @default.
• W2417996629 cites W2011508883 @default.
• W2417996629 cites W2022420575 @default.
• W2417996629 cites W2035715353 @default.
• W2417996629 cites W2049127704 @default.
• W2417996629 cites W2049446519 @default.
• W2417996629 cites W2051635571 @default.
• W2417996629 cites W2061580340 @default.
• W2417996629 cites W2070884121 @default.
• W2417996629 cites W2084774418 @default.
• W2417996629 cites W2093666814 @default.
• W2417996629 cites W2095398342 @default.
• W2417996629 cites W2101831374 @default.
• W2417996629 cites W2113891001 @default.
• W2417996629 cites W2153006626 @default.
• W2417996629 cites W2178797281 @default.
• W2417996629 cites W2332313529 @default.
• W2417996629 cites W2396385786 @default.
• W2417996629 cites W2397984585 @default.
• W2417996629 cites W2409704987 @default.
• W2417996629 cites W2411088366 @default.
• W2417996629 cites W2415371444 @default.
• W2417996629 cites W2417760965 @default.
• W2417996629 cites W2467011172 @default.
• W2417996629 cites W2470337057 @default.
• W2417996629 cites W2471203099 @default.
• W2417996629 cites W2888927728 @default.
• W2417996629 cites W2994056130 @default.
• W2417996629 cites W325553294 @default.
• W2417996629 cites W83073700 @default.
• W2417996629 doi "https://doi.org/10.1055/s-0038-1649646" @default.
• W2417996629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8115993" @default.
• W2417996629 hasPublicationYear "1993" @default.
• W2417996629 type Work @default.
• W2417996629 sameAs 2417996629 @default.
• W2417996629 citedByCount "128" @default.
• W2417996629 countsByYear W24179966292012 @default.
• W2417996629 countsByYear W24179966292013 @default.
• W2417996629 countsByYear W24179966292014 @default.
• W2417996629 countsByYear W24179966292015 @default.
• W2417996629 countsByYear W24179966292016 @default.
• W2417996629 countsByYear W24179966292017 @default.
• W2417996629 countsByYear W24179966292018 @default.
• W2417996629 countsByYear W24179966292020 @default.
• W2417996629 countsByYear W24179966292021 @default.
• W2417996629 countsByYear W24179966292022 @default.
• W2417996629 crossrefType "journal-article" @default.
• W2417996629 hasAuthorship W2417996629A5015334198 @default.
• W2417996629 hasAuthorship W2417996629A5042096585 @default.
• W2417996629 hasAuthorship W2417996629A5088588580 @default.
• W2417996629 hasAuthorship W2417996629A5091290798 @default.
• W2417996629 hasConcept C126322002 @default.
• W2417996629 hasConcept C134018914 @default.
• W2417996629 hasConcept C150903083 @default.
• W2417996629 hasConcept C159654299 @default.
• W2417996629 hasConcept C185592680 @default.
• W2417996629 hasConcept C203014093 @default.
• W2417996629 hasConcept C207001950 @default.
• W2417996629 hasConcept C2776785769 @default.
• W2417996629 hasConcept C2776874634 @default.
• W2417996629 hasConcept C2777292125 @default.
• W2417996629 hasConcept C2777477808 @default.
• W2417996629 hasConcept C2780664492 @default.
• W2417996629 hasConcept C2781024287 @default.
• W2417996629 hasConcept C2781080829 @default.
• W2417996629 hasConcept C2781128415 @default.
• W2417996629 hasConcept C3018697912 @default.
• W2417996629 hasConcept C71924100 @default.
• W2417996629 hasConcept C86803240 @default.
• W2417996629 hasConcept C89560881 @default.
• W2417996629 hasConcept C98274493 @default.
• W2417996629 hasConceptScore W2417996629C126322002 @default.
• W2417996629 hasConceptScore W2417996629C134018914 @default.
• W2417996629 hasConceptScore W2417996629C150903083 @default.
• W2417996629 hasConceptScore W2417996629C159654299 @default.
• W2417996629 hasConceptScore W2417996629C185592680 @default.
• W2417996629 hasConceptScore W2417996629C203014093 @default.
• W2417996629 hasConceptScore W2417996629C207001950 @default.
• W2417996629 hasConceptScore W2417996629C2776785769 @default.
• W2417996629 hasConceptScore W2417996629C2776874634 @default.
• W2417996629 hasConceptScore W2417996629C2777292125 @default.
• W2417996629 hasConceptScore W2417996629C2777477808 @default.

• next