Matches in SemOpenAlex for { <https://semopenalex.org/work/W2418002121> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2418002121 endingPage "C162" @default.
- W2418002121 startingPage "C156" @default.
- W2418002121 abstract "The whole cell patch-clamp technique was used to study ionic conductances in fetal distal lung epithelial (FDLE) cells. In unstimulated FDLE cells, K+ conductances were detected in lowered intracellular Cl- concentration ([Cl-]i, < or = 50 mM). The whole cell currents of FDLE cells were increased by elevation of intracellular Ca2+ concentration ([Ca2+]i) or intracellular adenosine 3',5'-cyclic monophosphate (cAMP) concentration ([cAMP]i). The elevation of [Ca2+]i activated the K+ currents. The amiloride-blockable whole cell currents were activated by [cAMP]i of 1 mM with [Cl-]i of 20 mM and were more frequently detected in the pipette solution without ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA) than with it (0.5 mM). When the [Cl-]i was fixed at 50 or 145 mM, however, the increase in these currents was not detected even with cAMP and without EGTA. The amiloride-blockable currents were detected in both the Na+ and K+ pipette solutions. Thus the increase in amiloride-blockable whole cell currents was due to the activation of nonselective cation channels. In FDLE cells treated with terbutaline, which is a beta 2-adrenergic receptor agonist, or forskolin, these currents were detected in the pipette solution containing 20 mM Cl- but were suppressed with time when the pipette solution contained 50 or 145 mM Cl-. It seems likely that maintenance of [Cl-]i at the lowered level is an important requirement for the FDLE cells to activate the amiloride-blockable whole cell currents. It is proposed that cellular mechanisms, such as cell shrinkage, exist to reduce the [Cl-]i in response to cAMP." @default.
- W2418002121 created "2016-06-24" @default.
- W2418002121 creator A5056790528 @default.
- W2418002121 creator A5082110892 @default.
- W2418002121 date "1995-07-01" @default.
- W2418002121 modified "2023-10-18" @default.
- W2418002121 title "Regulation of whole cell currents by cytosolic cAMP, Ca2+, and Cl- in rat fetal distal lung epithelium" @default.
- W2418002121 cites W1594482648 @default.
- W2418002121 cites W1964584239 @default.
- W2418002121 cites W1969946488 @default.
- W2418002121 cites W1996815527 @default.
- W2418002121 cites W2002565017 @default.
- W2418002121 cites W2020814457 @default.
- W2418002121 cites W2030191770 @default.
- W2418002121 cites W2048101981 @default.
- W2418002121 cites W2051661463 @default.
- W2418002121 cites W2055466685 @default.
- W2418002121 cites W2066614093 @default.
- W2418002121 cites W2069745890 @default.
- W2418002121 cites W2071462777 @default.
- W2418002121 cites W2083951231 @default.
- W2418002121 cites W2136782902 @default.
- W2418002121 cites W2154542824 @default.
- W2418002121 cites W2336583529 @default.
- W2418002121 cites W2395207614 @default.
- W2418002121 doi "https://doi.org/10.1152/ajpcell.1995.269.1.c156" @default.
- W2418002121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7631742" @default.
- W2418002121 hasPublicationYear "1995" @default.
- W2418002121 type Work @default.
- W2418002121 sameAs 2418002121 @default.
- W2418002121 citedByCount "20" @default.
- W2418002121 countsByYear W24180021212015 @default.
- W2418002121 crossrefType "journal-article" @default.
- W2418002121 hasAuthorship W2418002121A5056790528 @default.
- W2418002121 hasAuthorship W2418002121A5082110892 @default.
- W2418002121 hasConcept C12554922 @default.
- W2418002121 hasConcept C126322002 @default.
- W2418002121 hasConcept C134018914 @default.
- W2418002121 hasConcept C147789679 @default.
- W2418002121 hasConcept C147944092 @default.
- W2418002121 hasConcept C151552171 @default.
- W2418002121 hasConcept C170493617 @default.
- W2418002121 hasConcept C178790620 @default.
- W2418002121 hasConcept C185592680 @default.
- W2418002121 hasConcept C2777658833 @default.
- W2418002121 hasConcept C2779276759 @default.
- W2418002121 hasConcept C2779608910 @default.
- W2418002121 hasConcept C519063684 @default.
- W2418002121 hasConcept C537181965 @default.
- W2418002121 hasConcept C55493867 @default.
- W2418002121 hasConcept C71924100 @default.
- W2418002121 hasConcept C79879829 @default.
- W2418002121 hasConcept C86803240 @default.
- W2418002121 hasConceptScore W2418002121C12554922 @default.
- W2418002121 hasConceptScore W2418002121C126322002 @default.
- W2418002121 hasConceptScore W2418002121C134018914 @default.
- W2418002121 hasConceptScore W2418002121C147789679 @default.
- W2418002121 hasConceptScore W2418002121C147944092 @default.
- W2418002121 hasConceptScore W2418002121C151552171 @default.
- W2418002121 hasConceptScore W2418002121C170493617 @default.
- W2418002121 hasConceptScore W2418002121C178790620 @default.
- W2418002121 hasConceptScore W2418002121C185592680 @default.
- W2418002121 hasConceptScore W2418002121C2777658833 @default.
- W2418002121 hasConceptScore W2418002121C2779276759 @default.
- W2418002121 hasConceptScore W2418002121C2779608910 @default.
- W2418002121 hasConceptScore W2418002121C519063684 @default.
- W2418002121 hasConceptScore W2418002121C537181965 @default.
- W2418002121 hasConceptScore W2418002121C55493867 @default.
- W2418002121 hasConceptScore W2418002121C71924100 @default.
- W2418002121 hasConceptScore W2418002121C79879829 @default.
- W2418002121 hasConceptScore W2418002121C86803240 @default.
- W2418002121 hasIssue "1" @default.
- W2418002121 hasLocation W24180021211 @default.
- W2418002121 hasLocation W24180021212 @default.
- W2418002121 hasOpenAccess W2418002121 @default.
- W2418002121 hasPrimaryLocation W24180021211 @default.
- W2418002121 hasRelatedWork W1974658456 @default.
- W2418002121 hasRelatedWork W1983188520 @default.
- W2418002121 hasRelatedWork W2015979114 @default.
- W2418002121 hasRelatedWork W2064265775 @default.
- W2418002121 hasRelatedWork W2205040467 @default.
- W2418002121 hasRelatedWork W2315444311 @default.
- W2418002121 hasRelatedWork W2341817692 @default.
- W2418002121 hasRelatedWork W2414081612 @default.
- W2418002121 hasRelatedWork W2418002121 @default.
- W2418002121 hasRelatedWork W2358506810 @default.
- W2418002121 hasVolume "269" @default.
- W2418002121 isParatext "false" @default.
- W2418002121 isRetracted "false" @default.
- W2418002121 magId "2418002121" @default.
- W2418002121 workType "article" @default.