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- W2418071719 abstract "Abstract The ability of the kidney to form a concentrated urine at low rates of solute excretion as measured by osmotic UP ratio was studied during moderate dehydration in 5 essentially normal men. After 18 hours of water deprivation the osmotic UP ratios showed irregular variations which were not correlated with the serum total solute concentration and did not take the form of a diurnal rhythm. The osmotic UP ratio was measured after 18 to 22 hours of water deprivation on repeated occasions in 3 normal young men and found to vary between 3.6 and 4.3. This value was not increased by administration of vasopressin. The relationship between vasopressin dose, free water clearance, and osmotic UP ratio was examined in the same subjects after hydration. Although free water clearance became negative when vasopressin was given in doses of 18 to 26 mu. per hour, the highest osmotic UP ratios were not achieved until 42 to 100 mu. per hour was infused. UP ratios were then 3.7 to 4.1, values similar to those found in the same subjects during moderate dehydration." @default.
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- W2418071719 date "1958-09-01" @default.
- W2418071719 modified "2023-09-26" @default.
- W2418071719 title "Studies on the renal concentrating mechanism. I. Role of vasopressin." @default.
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