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• W2418111837 endingPage "849" @default.
• W2418111837 startingPage "843" @default.
• W2418111837 abstract "A chiral ligand-exchange high-performance liquid chromatography method was developed for the enantioseparation of ofloxacin and its six related substances termed impurities A, B, C, D, E, and F. The separation was performed on a conventional C18 column. Different organic modifiers, copper salts, amino acids, the ratio of Cu(2+) to amino acid, pH of aqueous phase, and column temperature were optimized. The optimal mobile phase conditions were methanol-water systems consisting of 5 mmol/L copper sulfate and 10 mmol/L L-isoleucine (L-Ile). Under such conditions, good enantioseparation of ofloxacin and impurities A, C, E, and F could be observed with resolutions (RS ) of 3.54, 1.97, 3.21, 3.50, and 2.12, respectively. On the relationship between the thermodynamic parameters and structures of analytes, the mechanism of chiral recognition was investigated. It was concluded that ofloxacin and impurities A, C, E, and F were all enthalpically driven enantioseparation and that low column temperature was beneficial to enantioseparation. Furthermore, the structure-separation relationship of these analytes is also discussed." @default.
• W2418111837 created "2016-06-24" @default.
• W2418111837 creator A5014303029 @default.
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• W2418111837 date "2015-09-17" @default.
• W2418111837 modified "2023-10-08" @default.
• W2418111837 title "Separation of Ofloxacin and Its Six Related Substances Enantiomers by Chiral Ligand-Exchange Chromatography" @default.
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• W2418111837 doi "https://doi.org/10.1002/chir.22527" @default.
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• W2418111837 hasPublicationYear "2015" @default.
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