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- W2418228359 abstract "Summary 1. Study objective: To determine whether single injections of Hirulog, a direct thrombin inhibitor, can inhibit thrombin generation in patients with calf vein thrombosis and, if so, if the inhibition is sustained. 2. Design: Phase II open label cohort study. 3. Setting: Tertiary-care referral centres, university affiliated hospitals. 4. Patients: 10 patients with venographically-demonstrated calf vein thrombosis. 5. Intervention: Patients received a single injection of Hirulog, either 1.0 mg/kg subcutaneously or 0.6 mg/kg as a 15 min intravenous infusion. Prothrombin fragment (F1+2) levels, as an index of thrombin generation, were measured before as well as 6 h post- and 24 h post-Hirulog administration. Patients were followed with non-invasive tests to detect thrombus extension into the proximal veins. 6. Results: There was a significant reduction in the levels of F1+2 with both regimens, 6 h after Hirulog. The Fl+2 levels 24 h post-Hirulog showed a significant increase relative to the 6 h post-Hirulog results. One patient developed thrombus extension into the popliteal vein and was treated with conventional anticoagulants. 7. Conclusion: The single injections of Hirulog used in the study produced incomplete and temporary suppression of F1+2. Complete and permanent inhibition of thrombin generation with Hirulog in patients with calf vein thrombosis may require higher doses, multiple subcutaneous injections and/or prolonged intravenous infusion." @default.
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- W2418228359 date "1994-01-01" @default.
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- W2418228359 title "Effects on Thrombin Generation of Single Injections of Hirulog™ in Patients with Calf Vein Thrombosis" @default.
- W2418228359 doi "https://doi.org/10.1055/s-0038-1648907" @default.
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