FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2418236948> ?p ?o ?g. }

• W2418236948 abstract "Abstract Highly purified (97%-99%) and viable (99%) peripheral blood monocytes obtained by EDTA-reversible adherence to autologous-serum-precoated plastic surfaces could rapidly lyse a variety of tumor cells in a 3–4 hr 51Cr release assay. Using these monocytes as effectors, a short-term agarose/conjugate assay was utilized, permitting us to examine the interaction between fresh human monocytes and neoplastic target cells on a single cell level. That the tumor-bound effector cells were indeed monocytes was confirmed by employing the monocyte-specific monoclonal antibody 61D3, which stained 95%-99% of the mononuclear cells bound to conjugated and killed K562 tumor targets. The binding of monocytes to target cells appeared to be temperature dependent and was extremely rapid, reaching a plateau after 5 min at 30 degrees C. Our findings demonstrated for the first time that only a proportion of human blood monocytes can bind to a particular target cell and that only a fraction of the binding cells have the intrinsic potential to kill those neoplastic targets. The proportion of monocytes capable of binding and killing varies between individuals and also depends on the tumor cell used, indicating heterogeneity in the monocyte and tumor cell populations. The highest proportion of monocytes bind to the human erythromyeloid leukemia K562 cell line (13%-50%). The frequency of monocytes capable of killing K562 tumor cells is relatively low (7%- 13%). The system described here should be useful to study the heterogeneity of mononuclear phagocytes and to analyze the molecular basis of the interaction between those effector cells and neoplastic target cells." @default.
• W2418236948 created "2016-06-24" @default.
• W2418236948 creator A5008435062 @default.
• W2418236948 creator A5035678601 @default.
• W2418236948 creator A5067007422 @default.
• W2418236948 creator A5083340734 @default.
• W2418236948 date "1983-02-01" @default.
• W2418236948 modified "2023-10-01" @default.
• W2418236948 title "Characteristics and requirements of the interaction between human monocytes and tumor cells on the single cell level" @default.
• W2418236948 cites W118365878 @default.
• W2418236948 cites W130020229 @default.
• W2418236948 cites W1504875452 @default.
• W2418236948 cites W1538443270 @default.
• W2418236948 cites W1545376727 @default.
• W2418236948 cites W1546755008 @default.
• W2418236948 cites W1557398086 @default.
• W2418236948 cites W1565583818 @default.
• W2418236948 cites W1598448236 @default.
• W2418236948 cites W1604112032 @default.
• W2418236948 cites W1729011202 @default.
• W2418236948 cites W2006416369 @default.
• W2418236948 cites W2018941038 @default.
• W2418236948 cites W2036211713 @default.
• W2418236948 cites W2048940654 @default.
• W2418236948 cites W2055499537 @default.
• W2418236948 cites W2073480440 @default.
• W2418236948 cites W2073767866 @default.
• W2418236948 cites W2081328994 @default.
• W2418236948 cites W2142914566 @default.
• W2418236948 cites W2161082695 @default.
• W2418236948 cites W2337543356 @default.
• W2418236948 cites W2404831155 @default.
• W2418236948 cites W2408451931 @default.
• W2418236948 cites W2409263962 @default.
• W2418236948 cites W2412218107 @default.
• W2418236948 cites W2412901202 @default.
• W2418236948 cites W2436349597 @default.
• W2418236948 cites W98709666 @default.
• W2418236948 doi "https://doi.org/10.1182/blood.v61.2.390.390" @default.
• W2418236948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6401434" @default.
• W2418236948 hasPublicationYear "1983" @default.
• W2418236948 type Work @default.
• W2418236948 sameAs 2418236948 @default.
• W2418236948 citedByCount "16" @default.
• W2418236948 countsByYear W24182369482013 @default.
• W2418236948 crossrefType "journal-article" @default.
• W2418236948 hasAuthorship W2418236948A5008435062 @default.
• W2418236948 hasAuthorship W2418236948A5035678601 @default.
• W2418236948 hasAuthorship W2418236948A5067007422 @default.
• W2418236948 hasAuthorship W2418236948A5083340734 @default.
• W2418236948 hasBestOaLocation W24182369481 @default.
• W2418236948 hasConcept C137061746 @default.
• W2418236948 hasConcept C1491633281 @default.
• W2418236948 hasConcept C153911025 @default.
• W2418236948 hasConcept C159654299 @default.
• W2418236948 hasConcept C171122931 @default.
• W2418236948 hasConcept C183521119 @default.
• W2418236948 hasConcept C185592680 @default.
• W2418236948 hasConcept C202751555 @default.
• W2418236948 hasConcept C203014093 @default.
• W2418236948 hasConcept C2778461978 @default.
• W2418236948 hasConcept C2781184567 @default.
• W2418236948 hasConcept C502942594 @default.
• W2418236948 hasConcept C542903549 @default.
• W2418236948 hasConcept C54355233 @default.
• W2418236948 hasConcept C55493867 @default.
• W2418236948 hasConcept C81885089 @default.
• W2418236948 hasConcept C86803240 @default.
• W2418236948 hasConceptScore W2418236948C137061746 @default.
• W2418236948 hasConceptScore W2418236948C1491633281 @default.
• W2418236948 hasConceptScore W2418236948C153911025 @default.
• W2418236948 hasConceptScore W2418236948C159654299 @default.
• W2418236948 hasConceptScore W2418236948C171122931 @default.
• W2418236948 hasConceptScore W2418236948C183521119 @default.
• W2418236948 hasConceptScore W2418236948C185592680 @default.
• W2418236948 hasConceptScore W2418236948C202751555 @default.
• W2418236948 hasConceptScore W2418236948C203014093 @default.
• W2418236948 hasConceptScore W2418236948C2778461978 @default.
• W2418236948 hasConceptScore W2418236948C2781184567 @default.
• W2418236948 hasConceptScore W2418236948C502942594 @default.
• W2418236948 hasConceptScore W2418236948C542903549 @default.
• W2418236948 hasConceptScore W2418236948C54355233 @default.
• W2418236948 hasConceptScore W2418236948C55493867 @default.
• W2418236948 hasConceptScore W2418236948C81885089 @default.
• W2418236948 hasConceptScore W2418236948C86803240 @default.
• W2418236948 hasLocation W24182369481 @default.
• W2418236948 hasOpenAccess W2418236948 @default.
• W2418236948 hasPrimaryLocation W24182369481 @default.
• W2418236948 hasRelatedWork W117390686 @default.
• W2418236948 hasRelatedWork W118365878 @default.
• W2418236948 hasRelatedWork W130020229 @default.
• W2418236948 hasRelatedWork W1483568633 @default.
• W2418236948 hasRelatedWork W1525780137 @default.
• W2418236948 hasRelatedWork W1549622199 @default.
• W2418236948 hasRelatedWork W1569611141 @default.
• W2418236948 hasRelatedWork W1589586234 @default.
• W2418236948 hasRelatedWork W1638066522 @default.
• W2418236948 hasRelatedWork W1977727151 @default.
• W2418236948 hasRelatedWork W1991611398 @default.
• W2418236948 hasRelatedWork W1993159014 @default.

• next