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- W2418246257 abstract "Numerous studies have demonstrated a high prevalence of coronary thrombi in the early hours of acute myocardial infarction leading to a complete occlusion of the coronary artery. Thrombolysis and reperfusion in the very early hours can preserve jeopardized myocardium from necrosis. Using intravenous streptokinase early reperfusion can be achieved in 50% of the patients with occluded coronary arteries. Using rt-PA and prourokinase reperfusion rate is 60 to 70%. Both agents have more fibrin-specific activity, therefore the risk of bleedings is reduced. However, thrombolytic treatment with early reperfusion seems to be just the first step. Further procedures (percutaneous transluminal coronary angioplasty = PTCA or early bypass surgery) have to be added to improve not only the short-term but also the long-term prognosis. If the ongoing randomized trials confirm a significant reduction in mortality due to reperfusion and improved ventricular function this aggressive treatment of the evolving myocardial infarction will change our strategy from a symptomatical to a more causal therapy." @default.
- W2418246257 created "2016-06-24" @default.
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- W2418246257 date "1987-09-01" @default.
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- W2418246257 title "[Thrombolytic therapy in acute myocardial infarct]." @default.
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