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- W2418251131 abstract "In spite of intensive induction polychemotherapy and subsequent intensive postremission chemotherapy nearly one-half of the children with acute myelogenous leukemia (AML) still relapse with their disease and ultimately die of drug-resistant leukemia. High secondary remission rates have recently been reported by the application of high-dose cytosine arabinoside (HD ARA-C) alone or in combination with anthracyclines, asparaginase or m-AMSA [1, 3–5, 7, 8, 11]. Especially patients with AML refractory against conventional-dose ARA-C were shown to benefit from the use of HD ARA-C [6]. In 1985 Hiddemann and coworkers reported on the high antileukemic activity in refractory and relapsed AML in adults using the combination of HD ARA-C plus mitoxantrone [5]. In the same year the German multicenter AML-BFM study group decided to use this drug combination in children with refractory and relapsed AML. This report gives an update of the pediatric HD ARA-C/mitoxantrone study." @default.
- W2418251131 created "2016-06-24" @default.
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- W2418251131 date "1992-01-01" @default.
- W2418251131 modified "2023-09-27" @default.
- W2418251131 title "Treatment of Refractory and Relapsed Childhood Acute Myelogenous Leukemia with High-Dose Cytosine Arabinoside and Mitoxantrone (HAM): Results of the AML Relapse Study BFM-85" @default.
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- W2418251131 doi "https://doi.org/10.1007/978-3-642-76591-9_68" @default.
- W2418251131 hasPublicationYear "1992" @default.
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