FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2418256489> ?p ?o ?g. }

• W2418256489 endingPage "1580" @default.
• W2418256489 startingPage "1564" @default.
• W2418256489 abstract "The rapid growth of the nanotechnology industry has warranted equal progress in the nanotoxicology and risk assessment fields. In vivo models have traditionally been used to determine human and environmental risk for chemicals; however, the use of these tests has limitations, and there are global appeals to develop reliable alternatives to animal testing. Many have investigated the use of alternative (nonanimal) testing methods and strategies have quickly developed and resulted in the generation of large toxicological data sets for numerous nanomaterials (NMs). Due to the novel physicochemical properties of NMs that are related to surface characteristics, the approach toward toxicity test development has distinct considerations from traditional chemicals, bringing new requirements for adapting these approaches for NMs. The methodical development of strategies that combine multiple alternative tests can be useful for predictive NM risk assessment and help screening‐level decision making. This article provides an overview of the main developments in alternative methods and strategies for reducing uncertainty in NM risk assessment, including advantages and disadvantages of in vitro , ex vivo , and in silico methods, and examples of existing comprehensive strategies. In addition, knowledge gaps are identified toward improvements for experimental and strategy design, specifically highlighting the need to represent realistic exposure scenarios and to consider NM‐specific concerns such as characterization, assay interferences, and standardization. Overall, this article aims to improve the reliability and utility of alternative testing methods and strategies for risk assessment of manufactured NMs." @default.
• W2418256489 created "2016-06-24" @default.
• W2418256489 creator A5050937174 @default.
• W2418256489 creator A5061512726 @default.
• W2418256489 date "2016-06-07" @default.
• W2418256489 modified "2023-09-25" @default.
• W2418256489 title "Alternative Testing Strategies for Nanomaterials: State of the Science and Considerations for Risk Analysis" @default.
• W2418256489 cites W196523094 @default.
• W2418256489 cites W1965351120 @default.
• W2418256489 cites W1969896692 @default.
• W2418256489 cites W1977690715 @default.
• W2418256489 cites W1977785687 @default.
• W2418256489 cites W1979973526 @default.
• W2418256489 cites W1984044241 @default.
• W2418256489 cites W1984364967 @default.
• W2418256489 cites W1985656429 @default.
• W2418256489 cites W1986051175 @default.
• W2418256489 cites W1986437187 @default.
• W2418256489 cites W1992658358 @default.
• W2418256489 cites W1993100829 @default.
• W2418256489 cites W2000089305 @default.
• W2418256489 cites W2000975018 @default.
• W2418256489 cites W2001143171 @default.
• W2418256489 cites W2001931101 @default.
• W2418256489 cites W2003399960 @default.
• W2418256489 cites W2007952518 @default.
• W2418256489 cites W2009792330 @default.
• W2418256489 cites W2010516376 @default.
• W2418256489 cites W2012133139 @default.
• W2418256489 cites W2013520568 @default.
• W2418256489 cites W2018904844 @default.
• W2418256489 cites W2022955853 @default.
• W2418256489 cites W2027827546 @default.
• W2418256489 cites W2028250705 @default.
• W2418256489 cites W2030290838 @default.
• W2418256489 cites W2035538736 @default.
• W2418256489 cites W2036661308 @default.
• W2418256489 cites W2036798456 @default.
• W2418256489 cites W2039199691 @default.
• W2418256489 cites W2040539854 @default.
• W2418256489 cites W2041308432 @default.
• W2418256489 cites W2041473955 @default.
• W2418256489 cites W2045055151 @default.
• W2418256489 cites W2049426807 @default.
• W2418256489 cites W2053476691 @default.
• W2418256489 cites W2054378557 @default.
• W2418256489 cites W2059216445 @default.
• W2418256489 cites W2062815242 @default.
• W2418256489 cites W2074947593 @default.
• W2418256489 cites W2076922024 @default.
• W2418256489 cites W2084261722 @default.
• W2418256489 cites W2086060074 @default.
• W2418256489 cites W2086510163 @default.
• W2418256489 cites W2088760518 @default.
• W2418256489 cites W2089642206 @default.
• W2418256489 cites W2090507586 @default.
• W2418256489 cites W2099868663 @default.
• W2418256489 cites W2102736418 @default.
• W2418256489 cites W2102802141 @default.
• W2418256489 cites W2104488035 @default.
• W2418256489 cites W2112058534 @default.
• W2418256489 cites W2114330067 @default.
• W2418256489 cites W2117722565 @default.
• W2418256489 cites W2120521506 @default.
• W2418256489 cites W2121391010 @default.
• W2418256489 cites W2121566077 @default.
• W2418256489 cites W2125510179 @default.
• W2418256489 cites W2129779488 @default.
• W2418256489 cites W2129823011 @default.
• W2418256489 cites W2130815948 @default.
• W2418256489 cites W2131113741 @default.
• W2418256489 cites W2131755453 @default.
• W2418256489 cites W2133522926 @default.
• W2418256489 cites W2138344667 @default.
• W2418256489 cites W2142480093 @default.
• W2418256489 cites W2145795767 @default.
• W2418256489 cites W2151609134 @default.
• W2418256489 cites W2151988198 @default.
• W2418256489 cites W2152517410 @default.
• W2418256489 cites W2153197371 @default.
• W2418256489 cites W2159502819 @default.
• W2418256489 cites W2161721304 @default.
• W2418256489 cites W2163577514 @default.
• W2418256489 cites W2166298118 @default.
• W2418256489 cites W2166483762 @default.
• W2418256489 cites W2166553896 @default.
• W2418256489 cites W2168173850 @default.
• W2418256489 cites W2318370976 @default.
• W2418256489 cites W2320510241 @default.
• W2418256489 cites W60314632 @default.
• W2418256489 cites W79310657 @default.
• W2418256489 doi "https://doi.org/10.1111/risa.12642" @default.
• W2418256489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27273523" @default.
• W2418256489 hasPublicationYear "2016" @default.
• W2418256489 type Work @default.
• W2418256489 sameAs 2418256489 @default.
• W2418256489 citedByCount "20" @default.
• W2418256489 countsByYear W24182564892016 @default.

• next