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• W2418263387 startingPage "735" @default.
• W2418263387 abstract "We studied the inhibition of tumour necrosis factor alpha (TNFalpha)- and camptothecin-induced apoptosis by Bcl-2 and Bcl-xL as they relate to the ceramide pathway. Expression of either Bcl-2 or Bcl-xL provided significant protection from the apoptotic effects of TNFalpha or camptothecin. In contrast to Bcl-2, Bcl-xL overexpression did not protect cells from ceramide-induced apoptosis. On the other hand, Bcl-xL prevented the accumulation of endogenous ceramide in response to TNFalpha or camptothecin, whereas Bcl-2 showed little effect on ceramide formation. Moreover, Bcl-xL, but not Bcl-2, totally inhibited a caspase-8-like activity in cell lysates stimulated with TNFalpha. These results identify a different mechanism of action for Bcl-xL compared with Bcl-2 and they demonstrate that Bcl-xL targets a point upstream of ceramide generation, whereas Bcl-2 functions downstream of ceramide in the TNFalpha- and camptothecin-activated pathways of apoptosis." @default.
• W2418263387 created "2016-06-24" @default.
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• W2418263387 date "1998-12-15" @default.
• W2418263387 modified "2023-10-16" @default.
• W2418263387 title "Distinct sites of action of Bcl-2 and Bcl-xL in the ceramide pathway of apoptosis" @default.
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• W2418263387 doi "https://doi.org/10.1042/bj3360735" @default.
• W2418263387 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1219927" @default.
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• W2418263387 hasPublicationYear "1998" @default.
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