Matches in SemOpenAlex for { <https://semopenalex.org/work/W2418330981> ?p ?o ?g. }
- W2418330981 endingPage "758" @default.
- W2418330981 startingPage "750" @default.
- W2418330981 abstract "Recently approved multi-target inhibitors of receptor tyrosine kinases (RTKs) have significantly improved the clinical treatment of cancers. A series of N,N′-diarylureas incorporated with aromatic heterocycle have been designed, synthesized and evaluated as novel multi-target RTK inhibitors. The preliminary biological evaluation indicated that several compounds exhibited comparable potency with Sorafenib. Among them, compound 6f was identified as the most potent multikinase inhibitor of EGFR, KDR and FGFR1 with IC50 values of 14.83 nM, 21.57 nM, and 28.23 nM, respectively. These compounds expanded the structural diversity of diarylureas as RTK inhibitors. The results demonstrated that compound 6f could be served as novel lead compound for further development of multi-target RTK inhibitors." @default.
- W2418330981 created "2016-06-24" @default.
- W2418330981 creator A5012880290 @default.
- W2418330981 creator A5013038112 @default.
- W2418330981 creator A5021541475 @default.
- W2418330981 creator A5047170684 @default.
- W2418330981 creator A5053087884 @default.
- W2418330981 creator A5057782222 @default.
- W2418330981 date "2016-02-01" @default.
- W2418330981 modified "2023-10-15" @default.
- W2418330981 title "Expanding the structural diversity of diarylureas as multi-target tyrosine kinase inhibitors" @default.
- W2418330981 cites W1535085915 @default.
- W2418330981 cites W1927262698 @default.
- W2418330981 cites W1969001441 @default.
- W2418330981 cites W1972317743 @default.
- W2418330981 cites W1976431897 @default.
- W2418330981 cites W1998763573 @default.
- W2418330981 cites W2024320541 @default.
- W2418330981 cites W2024447293 @default.
- W2418330981 cites W2033285233 @default.
- W2418330981 cites W2044687642 @default.
- W2418330981 cites W2059732801 @default.
- W2418330981 cites W2072122458 @default.
- W2418330981 cites W2072827911 @default.
- W2418330981 cites W2073855200 @default.
- W2418330981 cites W2078297622 @default.
- W2418330981 cites W2087764699 @default.
- W2418330981 cites W2101174827 @default.
- W2418330981 cites W2168752603 @default.
- W2418330981 cites W2172586978 @default.
- W2418330981 cites W2177317749 @default.
- W2418330981 cites W2182002921 @default.
- W2418330981 cites W2322445737 @default.
- W2418330981 cites W2327451947 @default.
- W2418330981 cites W2332019204 @default.
- W2418330981 doi "https://doi.org/10.1016/j.bmc.2015.12.038" @default.
- W2418330981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26753815" @default.
- W2418330981 hasPublicationYear "2016" @default.
- W2418330981 type Work @default.
- W2418330981 sameAs 2418330981 @default.
- W2418330981 citedByCount "16" @default.
- W2418330981 countsByYear W24183309812016 @default.
- W2418330981 countsByYear W24183309812017 @default.
- W2418330981 countsByYear W24183309812018 @default.
- W2418330981 countsByYear W24183309812020 @default.
- W2418330981 countsByYear W24183309812021 @default.
- W2418330981 countsByYear W24183309812022 @default.
- W2418330981 countsByYear W24183309812023 @default.
- W2418330981 crossrefType "journal-article" @default.
- W2418330981 hasAuthorship W2418330981A5012880290 @default.
- W2418330981 hasAuthorship W2418330981A5013038112 @default.
- W2418330981 hasAuthorship W2418330981A5021541475 @default.
- W2418330981 hasAuthorship W2418330981A5047170684 @default.
- W2418330981 hasAuthorship W2418330981A5053087884 @default.
- W2418330981 hasAuthorship W2418330981A5057782222 @default.
- W2418330981 hasConcept C101544691 @default.
- W2418330981 hasConcept C121608353 @default.
- W2418330981 hasConcept C126322002 @default.
- W2418330981 hasConcept C170493617 @default.
- W2418330981 hasConcept C184235292 @default.
- W2418330981 hasConcept C185592680 @default.
- W2418330981 hasConcept C193042331 @default.
- W2418330981 hasConcept C202751555 @default.
- W2418330981 hasConcept C21951064 @default.
- W2418330981 hasConcept C2777752112 @default.
- W2418330981 hasConcept C2777752497 @default.
- W2418330981 hasConcept C2778019345 @default.
- W2418330981 hasConcept C2778695046 @default.
- W2418330981 hasConcept C2778820342 @default.
- W2418330981 hasConcept C2909867262 @default.
- W2418330981 hasConcept C2911166042 @default.
- W2418330981 hasConcept C42362537 @default.
- W2418330981 hasConcept C502942594 @default.
- W2418330981 hasConcept C55493867 @default.
- W2418330981 hasConcept C57992300 @default.
- W2418330981 hasConcept C71240020 @default.
- W2418330981 hasConcept C71924100 @default.
- W2418330981 hasConcept C86803240 @default.
- W2418330981 hasConcept C98274493 @default.
- W2418330981 hasConceptScore W2418330981C101544691 @default.
- W2418330981 hasConceptScore W2418330981C121608353 @default.
- W2418330981 hasConceptScore W2418330981C126322002 @default.
- W2418330981 hasConceptScore W2418330981C170493617 @default.
- W2418330981 hasConceptScore W2418330981C184235292 @default.
- W2418330981 hasConceptScore W2418330981C185592680 @default.
- W2418330981 hasConceptScore W2418330981C193042331 @default.
- W2418330981 hasConceptScore W2418330981C202751555 @default.
- W2418330981 hasConceptScore W2418330981C21951064 @default.
- W2418330981 hasConceptScore W2418330981C2777752112 @default.
- W2418330981 hasConceptScore W2418330981C2777752497 @default.
- W2418330981 hasConceptScore W2418330981C2778019345 @default.
- W2418330981 hasConceptScore W2418330981C2778695046 @default.
- W2418330981 hasConceptScore W2418330981C2778820342 @default.
- W2418330981 hasConceptScore W2418330981C2909867262 @default.
- W2418330981 hasConceptScore W2418330981C2911166042 @default.
- W2418330981 hasConceptScore W2418330981C42362537 @default.
- W2418330981 hasConceptScore W2418330981C502942594 @default.
- W2418330981 hasConceptScore W2418330981C55493867 @default.