FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2418348567> ?p ?o ?g. }

• W2418348567 endingPage "3009" @default.
• W2418348567 startingPage "3002" @default.
• W2418348567 abstract "Bile acids regulate lipid and carbohydrate metabolism by interaction with membrane or intracellular proteins including the nuclear farnesoid X receptor (FXR). Postprandial activation of ileal FXR leads to secretion of fibroblast growth factor 19 (FGF-19), a gut hormone that may be implicated in postprandial glucose metabolism. To describe postprandial plasma concentrations of 12 individual bile acids and FGF-19 in patients with type 2 diabetes (T2D) and healthy controls. Descriptive study, performed at the Center for Diabetes Research, Gentofte Hospital, Hellerup, Denmark. Fifteen patients with T2D and 15 healthy matched controls with normal glucose tolerance. A 75-g oral glucose tolerance test and three isocaloric and isovolemic liquid meals with low, medium, and high fat content, respectively. Bile acid and FGF-19 concentrations. Postprandial total bile acid concentrations increased with increasing meal fat content (P < .05), peaked after 1–2 hours, and were higher in T2D patients vs controls (oral glucose tolerance test, low and medium fat meals, P < .05; high fat meal, P = .30). Differences reflected mainly unconjugated and glycine-conjugated forms of deoxycholic acid (DCA) and to a lesser extent cholic acid (CA) and ursodeoxycholic acid (UDCA), whereas chenodeoxycholic acid (CDCA) concentrations were comparable in the two groups. FGF-19 concentrations tended to be lower in T2D patients vs controls, but differences were not statistically significant due to considerable variation. Postprandial plasma patterns of bile acids with FXR agonistic properties (CDCA, DCA, and CA) and FXR antagonistic properties (UDCA) in T2D patients support the notion of a “T2D-bile acid-FGF-19” phenotype with possible pathophysiological implications. Postprandial plasma concentrations of 12 bile acids and FGF-19 were measured in patients with T2D and matched controls. Results support the notion of a ‘T2D-bile acid FGF-19’ phenotype with possible pathophysiological implications." @default.
• W2418348567 created "2016-06-24" @default.
• W2418348567 creator A5004120950 @default.
• W2418348567 creator A5010029482 @default.
• W2418348567 creator A5068479225 @default.
• W2418348567 creator A5076536522 @default.
• W2418348567 creator A5079352451 @default.
• W2418348567 creator A5082493161 @default.
• W2418348567 date "2016-08-01" @default.
• W2418348567 modified "2023-10-01" @default.
• W2418348567 title "Postprandial Plasma Concentrations of Individual Bile Acids and FGF-19 in Patients With Type 2 Diabetes" @default.
• W2418348567 cites W1564206240 @default.
• W2418348567 cites W1821582942 @default.
• W2418348567 cites W1901029932 @default.
• W2418348567 cites W1918619761 @default.
• W2418348567 cites W1969668125 @default.
• W2418348567 cites W1973529232 @default.
• W2418348567 cites W1975673963 @default.
• W2418348567 cites W1978260763 @default.
• W2418348567 cites W1983228333 @default.
• W2418348567 cites W1983797849 @default.
• W2418348567 cites W1985209274 @default.
• W2418348567 cites W1987843898 @default.
• W2418348567 cites W1989023250 @default.
• W2418348567 cites W2003905949 @default.
• W2418348567 cites W2008471359 @default.
• W2418348567 cites W2014959360 @default.
• W2418348567 cites W2020515276 @default.
• W2418348567 cites W2022279737 @default.
• W2418348567 cites W2041451676 @default.
• W2418348567 cites W2047037780 @default.
• W2418348567 cites W2050856495 @default.
• W2418348567 cites W2052638070 @default.
• W2418348567 cites W2053302563 @default.
• W2418348567 cites W2063009130 @default.
• W2418348567 cites W2097232483 @default.
• W2418348567 cites W2099292171 @default.
• W2418348567 cites W2100235230 @default.
• W2418348567 cites W2104004584 @default.
• W2418348567 cites W2105866876 @default.
• W2418348567 cites W2106986971 @default.
• W2418348567 cites W2113961306 @default.
• W2418348567 cites W2129512027 @default.
• W2418348567 cites W2138399473 @default.
• W2418348567 cites W2138711524 @default.
• W2418348567 cites W2156257382 @default.
• W2418348567 cites W2156356963 @default.
• W2418348567 cites W2158609797 @default.
• W2418348567 cites W2186146257 @default.
• W2418348567 cites W2283376353 @default.
• W2418348567 doi "https://doi.org/10.1210/jc.2016-1607" @default.
• W2418348567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27270475" @default.
• W2418348567 hasPublicationYear "2016" @default.
• W2418348567 type Work @default.
• W2418348567 sameAs 2418348567 @default.
• W2418348567 citedByCount "89" @default.
• W2418348567 countsByYear W24183485672016 @default.
• W2418348567 countsByYear W24183485672017 @default.
• W2418348567 countsByYear W24183485672018 @default.
• W2418348567 countsByYear W24183485672019 @default.
• W2418348567 countsByYear W24183485672020 @default.
• W2418348567 countsByYear W24183485672021 @default.
• W2418348567 countsByYear W24183485672022 @default.
• W2418348567 countsByYear W24183485672023 @default.
• W2418348567 crossrefType "journal-article" @default.
• W2418348567 hasAuthorship W2418348567A5004120950 @default.
• W2418348567 hasAuthorship W2418348567A5010029482 @default.
• W2418348567 hasAuthorship W2418348567A5068479225 @default.
• W2418348567 hasAuthorship W2418348567A5076536522 @default.
• W2418348567 hasAuthorship W2418348567A5079352451 @default.
• W2418348567 hasAuthorship W2418348567A5082493161 @default.
• W2418348567 hasBestOaLocation W24183485671 @default.
• W2418348567 hasConcept C104317684 @default.
• W2418348567 hasConcept C126322002 @default.
• W2418348567 hasConcept C134018914 @default.
• W2418348567 hasConcept C170493617 @default.
• W2418348567 hasConcept C185592680 @default.
• W2418348567 hasConcept C203862802 @default.
• W2418348567 hasConcept C2775900799 @default.
• W2418348567 hasConcept C2775936931 @default.
• W2418348567 hasConcept C2777180221 @default.
• W2418348567 hasConcept C2778199505 @default.
• W2418348567 hasConcept C2779306644 @default.
• W2418348567 hasConcept C2779399885 @default.
• W2418348567 hasConcept C2780749602 @default.
• W2418348567 hasConcept C2780965833 @default.
• W2418348567 hasConcept C2781089062 @default.
• W2418348567 hasConcept C55493867 @default.
• W2418348567 hasConcept C555293320 @default.
• W2418348567 hasConcept C63932345 @default.
• W2418348567 hasConcept C71924100 @default.
• W2418348567 hasConcept C74373430 @default.
• W2418348567 hasConcept C86339819 @default.
• W2418348567 hasConceptScore W2418348567C104317684 @default.
• W2418348567 hasConceptScore W2418348567C126322002 @default.
• W2418348567 hasConceptScore W2418348567C134018914 @default.
• W2418348567 hasConceptScore W2418348567C170493617 @default.
• W2418348567 hasConceptScore W2418348567C185592680 @default.

• next