Matches in SemOpenAlex for { <https://semopenalex.org/work/W2418371217> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2418371217 endingPage "6" @default.
- W2418371217 startingPage "3" @default.
- W2418371217 abstract "In the programme for screening sterol synthesis inhibitors with the use of actinomycetes and fungi 702 strains were tested. The effect of alcohol extracts of the mycelium of fungi and actinomycetes at a dilution of 1/10(3) on sterol synthesis by the Hep G2 hepatome cells was determined by incorporation of 3H acetate into sterols and proteins. Lovastatin (200 pg/ml) was used as the control: the sterol synthesis was decreased by 49 +/- 4% without inhibiting the protein synthesis. A number of the cultures produced compounds inhibiting under the experimental conditions the synthesis of sterols by 70 to 80% with simultaneous inhibition of the protein synthesis at least by 60 to 70%. Three compounds from that group produced by streptomycetes were subjected to a more detailed investigation. The compounds were demonstrated to be active antifungal antibiotics (MIC 0.1-1 mcg/ml). In a dose of 0.1-1 mcg/ml they showed high immunosuppressive activity in models of lymphocyte transformation in mice, whereas cyclosporin was active in a dose of 1 mcg/ml. Therefore, the model for screening hypolipidemic compounds could be considered useful for screening promising natural immunosuppressors." @default.
- W2418371217 created "2016-06-24" @default.
- W2418371217 creator A5017617536 @default.
- W2418371217 creator A5018664619 @default.
- W2418371217 creator A5022764010 @default.
- W2418371217 creator A5036805300 @default.
- W2418371217 creator A5038363936 @default.
- W2418371217 creator A5076386211 @default.
- W2418371217 date "2003-01-01" @default.
- W2418371217 modified "2023-09-23" @default.
- W2418371217 title "[Screening of natural immunosuppressors by their ability to modify steroid synthesis in hepatocytes]." @default.
- W2418371217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14722935" @default.
- W2418371217 hasPublicationYear "2003" @default.
- W2418371217 type Work @default.
- W2418371217 sameAs 2418371217 @default.
- W2418371217 citedByCount "0" @default.
- W2418371217 crossrefType "journal-article" @default.
- W2418371217 hasAuthorship W2418371217A5017617536 @default.
- W2418371217 hasAuthorship W2418371217A5018664619 @default.
- W2418371217 hasAuthorship W2418371217A5022764010 @default.
- W2418371217 hasAuthorship W2418371217A5036805300 @default.
- W2418371217 hasAuthorship W2418371217A5038363936 @default.
- W2418371217 hasAuthorship W2418371217A5076386211 @default.
- W2418371217 hasConcept C133479454 @default.
- W2418371217 hasConcept C185592680 @default.
- W2418371217 hasConcept C2778163477 @default.
- W2418371217 hasConcept C2778718757 @default.
- W2418371217 hasConcept C2780902042 @default.
- W2418371217 hasConcept C2780940807 @default.
- W2418371217 hasConcept C501593827 @default.
- W2418371217 hasConcept C55493867 @default.
- W2418371217 hasConcept C59822182 @default.
- W2418371217 hasConcept C71315377 @default.
- W2418371217 hasConcept C86803240 @default.
- W2418371217 hasConcept C98274493 @default.
- W2418371217 hasConceptScore W2418371217C133479454 @default.
- W2418371217 hasConceptScore W2418371217C185592680 @default.
- W2418371217 hasConceptScore W2418371217C2778163477 @default.
- W2418371217 hasConceptScore W2418371217C2778718757 @default.
- W2418371217 hasConceptScore W2418371217C2780902042 @default.
- W2418371217 hasConceptScore W2418371217C2780940807 @default.
- W2418371217 hasConceptScore W2418371217C501593827 @default.
- W2418371217 hasConceptScore W2418371217C55493867 @default.
- W2418371217 hasConceptScore W2418371217C59822182 @default.
- W2418371217 hasConceptScore W2418371217C71315377 @default.
- W2418371217 hasConceptScore W2418371217C86803240 @default.
- W2418371217 hasConceptScore W2418371217C98274493 @default.
- W2418371217 hasIssue "8" @default.
- W2418371217 hasLocation W24183712171 @default.
- W2418371217 hasOpenAccess W2418371217 @default.
- W2418371217 hasPrimaryLocation W24183712171 @default.
- W2418371217 hasRelatedWork W161986012 @default.
- W2418371217 hasRelatedWork W1631536383 @default.
- W2418371217 hasRelatedWork W188771143 @default.
- W2418371217 hasRelatedWork W1980504816 @default.
- W2418371217 hasRelatedWork W1995490285 @default.
- W2418371217 hasRelatedWork W2007951500 @default.
- W2418371217 hasRelatedWork W2114602369 @default.
- W2418371217 hasRelatedWork W2418371217 @default.
- W2418371217 hasRelatedWork W2898584665 @default.
- W2418371217 hasRelatedWork W2915380665 @default.
- W2418371217 hasVolume "48" @default.
- W2418371217 isParatext "false" @default.
- W2418371217 isRetracted "false" @default.
- W2418371217 magId "2418371217" @default.
- W2418371217 workType "article" @default.