Matches in SemOpenAlex for { <https://semopenalex.org/work/W2418396773> ?p ?o ?g. }
- W2418396773 endingPage "e2240" @default.
- W2418396773 startingPage "e2240" @default.
- W2418396773 abstract "Abstract Cerebellar degeneration-related protein 2 (cdr2) is expressed in the central nervous system, and its ectopic expression in tumor cells of patients with gynecological malignancies elicits immune responses by cdr2-specific autoantibodies and T lymphocytes, leading to neurological symptoms. However, little is known about the regulation and function of cdr2 in neurodegenerative diseases. Because we found that cdr2 is highly expressed in the midbrain, we investigated the role of cdr2 in experimental models of Parkinson’s disease (PD). We found that cdr2 levels were significantly reduced after stereotaxic injection of 1-methyl-4-phenylpyridinium (MPP + ) into the striatum. cdr2 levels were also decreased in the brains of post-mortem PD patients. Using primary cultures of mesencephalic neurons and MN9D cells, we confirmed that MPP + reduces cdr2 in tyrosine hydroxylase-positive dopaminergic neuronal cells. The MPP + -induced decrease of cdr2 was primarily caused by calpain- and ubiquitin proteasome system-mediated degradation, and cotreatment with pharmacological inhibitors of these enzymes or overexpression of calcium-binding protein rendered cells less vulnerable to MPP + -mediated cytotoxicity. Consequently, overexpression of cdr2 rescued cells from MPP + -induced cytotoxicity, whereas knockdown of cdr2 accelerated toxicity. Collectively, our findings provide insights into the novel regulatory mechanism and potentially protective role of onconeural protein during dopaminergic neurodegeneration." @default.
- W2418396773 created "2016-06-24" @default.
- W2418396773 creator A5004816267 @default.
- W2418396773 creator A5006006871 @default.
- W2418396773 creator A5013370468 @default.
- W2418396773 creator A5016127431 @default.
- W2418396773 creator A5019130790 @default.
- W2418396773 creator A5025236447 @default.
- W2418396773 creator A5035034609 @default.
- W2418396773 creator A5054007548 @default.
- W2418396773 creator A5062299005 @default.
- W2418396773 creator A5067720641 @default.
- W2418396773 creator A5075592373 @default.
- W2418396773 creator A5079280873 @default.
- W2418396773 creator A5081765715 @default.
- W2418396773 creator A5087269096 @default.
- W2418396773 creator A5090748788 @default.
- W2418396773 date "2016-06-02" @default.
- W2418396773 modified "2023-10-08" @default.
- W2418396773 title "Proteolytic degradation and potential role of onconeural protein cdr2 in neurodegeneration" @default.
- W2418396773 cites W1488137412 @default.
- W2418396773 cites W1488707762 @default.
- W2418396773 cites W1515948780 @default.
- W2418396773 cites W1807475000 @default.
- W2418396773 cites W187047728 @default.
- W2418396773 cites W1880554341 @default.
- W2418396773 cites W1964901370 @default.
- W2418396773 cites W1974074671 @default.
- W2418396773 cites W1974335219 @default.
- W2418396773 cites W1977434420 @default.
- W2418396773 cites W1981303911 @default.
- W2418396773 cites W1981713105 @default.
- W2418396773 cites W1985917760 @default.
- W2418396773 cites W1986216002 @default.
- W2418396773 cites W1992136431 @default.
- W2418396773 cites W1992673078 @default.
- W2418396773 cites W1993633932 @default.
- W2418396773 cites W1998225973 @default.
- W2418396773 cites W2011366786 @default.
- W2418396773 cites W2012403244 @default.
- W2418396773 cites W2014266239 @default.
- W2418396773 cites W2028091371 @default.
- W2418396773 cites W2033317217 @default.
- W2418396773 cites W2034118847 @default.
- W2418396773 cites W2034969914 @default.
- W2418396773 cites W2037704820 @default.
- W2418396773 cites W2038218537 @default.
- W2418396773 cites W2041555606 @default.
- W2418396773 cites W2052989598 @default.
- W2418396773 cites W2054319504 @default.
- W2418396773 cites W2061294779 @default.
- W2418396773 cites W2074526615 @default.
- W2418396773 cites W2076008898 @default.
- W2418396773 cites W2076715255 @default.
- W2418396773 cites W2076902968 @default.
- W2418396773 cites W2082667070 @default.
- W2418396773 cites W2092226919 @default.
- W2418396773 cites W2092876789 @default.
- W2418396773 cites W2096298540 @default.
- W2418396773 cites W2104140249 @default.
- W2418396773 cites W2105337439 @default.
- W2418396773 cites W2117724384 @default.
- W2418396773 cites W2124583600 @default.
- W2418396773 cites W2127242191 @default.
- W2418396773 cites W2129860046 @default.
- W2418396773 cites W2140283306 @default.
- W2418396773 cites W2141862164 @default.
- W2418396773 cites W2145954079 @default.
- W2418396773 cites W2150881749 @default.
- W2418396773 cites W2151796024 @default.
- W2418396773 cites W2158009878 @default.
- W2418396773 cites W2160697936 @default.
- W2418396773 cites W2162846693 @default.
- W2418396773 cites W2169681364 @default.
- W2418396773 cites W2169905941 @default.
- W2418396773 cites W2268781774 @default.
- W2418396773 cites W4302924100 @default.
- W2418396773 cites W4378799277 @default.
- W2418396773 cites W62603772 @default.
- W2418396773 cites W807957883 @default.
- W2418396773 doi "https://doi.org/10.1038/cddis.2016.151" @default.
- W2418396773 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5143381" @default.
- W2418396773 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27253404" @default.
- W2418396773 hasPublicationYear "2016" @default.
- W2418396773 type Work @default.
- W2418396773 sameAs 2418396773 @default.
- W2418396773 citedByCount "10" @default.
- W2418396773 countsByYear W24183967732017 @default.
- W2418396773 countsByYear W24183967732018 @default.
- W2418396773 countsByYear W24183967732019 @default.
- W2418396773 countsByYear W24183967732020 @default.
- W2418396773 countsByYear W24183967732022 @default.
- W2418396773 crossrefType "journal-article" @default.
- W2418396773 hasAuthorship W2418396773A5004816267 @default.
- W2418396773 hasAuthorship W2418396773A5006006871 @default.
- W2418396773 hasAuthorship W2418396773A5013370468 @default.
- W2418396773 hasAuthorship W2418396773A5016127431 @default.
- W2418396773 hasAuthorship W2418396773A5019130790 @default.