Matches in SemOpenAlex for { <https://semopenalex.org/work/W2418441486> ?p ?o ?g. }
- W2418441486 endingPage "6506" @default.
- W2418441486 startingPage "6506" @default.
- W2418441486 abstract "The purpose of this study was to investigate the presence of type VI collagen and glial cells in idiopathic epiretinal membrane (iERM) and the role of TGF-β in the expression of collagens and α-smooth muscle actin (α-SMA) in retinal Müller cells.Idiopathic ERM samples from vitrectomy were analyzed for glial acidic fibrillary protein (GFAP), cellular retinaldehyde-binding protein (CRALBP), α-SMA, and type VI collagen using flat-mount immunohistochemistry. To study intracellular collagen expression in relation to cellular phenotype, spontaneously immortalized human Müller cells (MIO-M1) were treated with TGF-β1 for 48 hours, and the expression of α-SMA and intracellular type I, II, IV, and VI collagens was studied by using immunocytology. Findings in Müller cells were compared with those in fetal lung fibroblasts and newborn skin fibroblasts.A colocalization of GFAP/CRALBP and GFAP/α-SMA was found in iERM, indicating a dynamic process of activation of retinal Müller cells in vivo. Transforming growth factor-β1 induced up-regulation of α-SMA stress fibers in retinal Müller cells and both types of fibroblasts in vitro. The intracellular staining intensity of type I, II, and VI collagens was decreased in retinal Müller cells containing α-SMA stress fibers, whereas the intracellular staining intensity of type I and VI collagens in both types of fibroblasts was not affected.Type VI collagen and activated retinal Müller cells are present in iERM. Transforming growth factor-β1 induces an up-regulation of α-SMA stress fibers in retinal Müller cells and fibroblasts and appears to have a cell-specific effect on intracellular collagen expression." @default.
- W2418441486 created "2016-06-24" @default.
- W2418441486 creator A5018228118 @default.
- W2418441486 creator A5030637640 @default.
- W2418441486 creator A5033513947 @default.
- W2418441486 creator A5054535246 @default.
- W2418441486 creator A5056640120 @default.
- W2418441486 creator A5077652551 @default.
- W2418441486 creator A5078446985 @default.
- W2418441486 creator A5085645592 @default.
- W2418441486 date "2015-10-08" @default.
- W2418441486 modified "2023-09-30" @default.
- W2418441486 title "Immunohistochemical Evaluation of Idiopathic Epiretinal Membranes and In Vitro Studies on the Effect of TGF-β on Müller Cells" @default.
- W2418441486 cites W1505584712 @default.
- W2418441486 cites W1577040882 @default.
- W2418441486 cites W1583526405 @default.
- W2418441486 cites W187955340 @default.
- W2418441486 cites W1912727058 @default.
- W2418441486 cites W1915110676 @default.
- W2418441486 cites W1965545142 @default.
- W2418441486 cites W1967428097 @default.
- W2418441486 cites W1973087217 @default.
- W2418441486 cites W1983176000 @default.
- W2418441486 cites W1989965800 @default.
- W2418441486 cites W2000401548 @default.
- W2418441486 cites W2010447678 @default.
- W2418441486 cites W2018358706 @default.
- W2418441486 cites W2019958345 @default.
- W2418441486 cites W2029043082 @default.
- W2418441486 cites W2030332537 @default.
- W2418441486 cites W2031869329 @default.
- W2418441486 cites W2034152019 @default.
- W2418441486 cites W2034242793 @default.
- W2418441486 cites W2041592617 @default.
- W2418441486 cites W2042873837 @default.
- W2418441486 cites W2048035811 @default.
- W2418441486 cites W2051942356 @default.
- W2418441486 cites W2060889734 @default.
- W2418441486 cites W2065439507 @default.
- W2418441486 cites W2066312038 @default.
- W2418441486 cites W2068773257 @default.
- W2418441486 cites W2073008993 @default.
- W2418441486 cites W2081195039 @default.
- W2418441486 cites W2083008063 @default.
- W2418441486 cites W2084527892 @default.
- W2418441486 cites W2088083220 @default.
- W2418441486 cites W2090875242 @default.
- W2418441486 cites W2092395752 @default.
- W2418441486 cites W2095470983 @default.
- W2418441486 cites W2106394177 @default.
- W2418441486 cites W2122808924 @default.
- W2418441486 cites W2148437651 @default.
- W2418441486 cites W2151381771 @default.
- W2418441486 cites W2160698607 @default.
- W2418441486 cites W2166851454 @default.
- W2418441486 cites W2167556128 @default.
- W2418441486 cites W2168111786 @default.
- W2418441486 cites W2336238444 @default.
- W2418441486 cites W70021726 @default.
- W2418441486 cites W2020085137 @default.
- W2418441486 cites W2044914889 @default.
- W2418441486 cites W2152961626 @default.
- W2418441486 doi "https://doi.org/10.1167/iovs.14-15971" @default.
- W2418441486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26447986" @default.
- W2418441486 hasPublicationYear "2015" @default.
- W2418441486 type Work @default.
- W2418441486 sameAs 2418441486 @default.
- W2418441486 citedByCount "41" @default.
- W2418441486 countsByYear W24184414862016 @default.
- W2418441486 countsByYear W24184414862017 @default.
- W2418441486 countsByYear W24184414862018 @default.
- W2418441486 countsByYear W24184414862019 @default.
- W2418441486 countsByYear W24184414862020 @default.
- W2418441486 countsByYear W24184414862021 @default.
- W2418441486 countsByYear W24184414862022 @default.
- W2418441486 countsByYear W24184414862023 @default.
- W2418441486 crossrefType "journal-article" @default.
- W2418441486 hasAuthorship W2418441486A5018228118 @default.
- W2418441486 hasAuthorship W2418441486A5030637640 @default.
- W2418441486 hasAuthorship W2418441486A5033513947 @default.
- W2418441486 hasAuthorship W2418441486A5054535246 @default.
- W2418441486 hasAuthorship W2418441486A5056640120 @default.
- W2418441486 hasAuthorship W2418441486A5077652551 @default.
- W2418441486 hasAuthorship W2418441486A5078446985 @default.
- W2418441486 hasAuthorship W2418441486A5085645592 @default.
- W2418441486 hasBestOaLocation W24184414861 @default.
- W2418441486 hasConcept C118131993 @default.
- W2418441486 hasConcept C142724271 @default.
- W2418441486 hasConcept C153911025 @default.
- W2418441486 hasConcept C169760540 @default.
- W2418441486 hasConcept C185592680 @default.
- W2418441486 hasConcept C203014093 @default.
- W2418441486 hasConcept C204232928 @default.
- W2418441486 hasConcept C2777093970 @default.
- W2418441486 hasConcept C2779059073 @default.
- W2418441486 hasConcept C2780428090 @default.
- W2418441486 hasConcept C2780495277 @default.
- W2418441486 hasConcept C2780644872 @default.