Matches in SemOpenAlex for { <https://semopenalex.org/work/W2418446007> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2418446007 endingPage "421" @default.
- W2418446007 startingPage "418" @default.
- W2418446007 abstract "Objective To investigate the role of sperm fluorescence in situ hybridization (FISH) in preimplantation genetic diagnosis (PGD) for male chromosomal disorders. Methods From Jul. 2006 to Aug. 2008, FISH was performed in sperm and embryo of 9 infertile couples due to male chromosomal abnormality including 7 couples with Robertsonian translocation, one couple with reciprocal translocation and one couple with Klinefelter's syndrome. Correlation analysis was performed between sperm and embryo FISH results. Results (1) FISH analysis of 8568 sperms showed 24 sperms had no fluorescence signals. The rate of normal/balanced sperm of carders were 85.71% (6045/7053)in seven Robertsonian translocation, 30.42% (306/1006) in one reciprocal translocation and 68.76% (350/509) in Klinefeher's syndrome. (2) A total of 158 embryos were biopsied, of which 135 embryos were successfully fixed for FISH. A hundred and one embryos exhibit informative signal including 36 normal/balanced embryos and 75 abnormal embryos. Twenty-one embryos were transferred and one couple obtained successful term pregnancy. The rate of normal/balanced embryo were 29.0% (31/107) in 7 carriers of Robertsonian translocation, 6.3% (1/16) in one reciprocal translocation and 33.3% (4/12) in Klinefeher' s syndrome. (3) A positive correlated relationship was found between the percentage of normal embryo and the percentage of normal sperm (r= 0.75,P=0.02). Conclusion It is advisable to recommend the sperm FISH analysis for being routinely incorporated into the genetic screening offered prior to preimplantation genetic diagnosis.Key words: Preimplantation diagnosis; Chromosome aberrations; In situ hybridization; fluorescence; Spermatozoa" @default.
- W2418446007 created "2016-06-24" @default.
- W2418446007 creator A5006219539 @default.
- W2418446007 creator A5020174688 @default.
- W2418446007 creator A5044537971 @default.
- W2418446007 creator A5057064387 @default.
- W2418446007 creator A5084043651 @default.
- W2418446007 date "2009-06-01" @default.
- W2418446007 modified "2023-09-22" @default.
- W2418446007 title "Application of sperm fluorescence in situ hybridization in preimplantation genetic diagnosis" @default.
- W2418446007 doi "https://doi.org/10.3760/cma.j.issn.0529-567x.2009.06.005" @default.
- W2418446007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19953940" @default.
- W2418446007 hasPublicationYear "2009" @default.
- W2418446007 type Work @default.
- W2418446007 sameAs 2418446007 @default.
- W2418446007 citedByCount "0" @default.
- W2418446007 crossrefType "journal-article" @default.
- W2418446007 hasAuthorship W2418446007A5006219539 @default.
- W2418446007 hasAuthorship W2418446007A5020174688 @default.
- W2418446007 hasAuthorship W2418446007A5044537971 @default.
- W2418446007 hasAuthorship W2418446007A5057064387 @default.
- W2418446007 hasAuthorship W2418446007A5084043651 @default.
- W2418446007 hasConcept C104317684 @default.
- W2418446007 hasConcept C138626823 @default.
- W2418446007 hasConcept C16685009 @default.
- W2418446007 hasConcept C196843134 @default.
- W2418446007 hasConcept C2777542201 @default.
- W2418446007 hasConcept C2778805741 @default.
- W2418446007 hasConcept C2780458022 @default.
- W2418446007 hasConcept C2781087480 @default.
- W2418446007 hasConcept C30481170 @default.
- W2418446007 hasConcept C53226629 @default.
- W2418446007 hasConcept C54355233 @default.
- W2418446007 hasConcept C71924100 @default.
- W2418446007 hasConcept C86803240 @default.
- W2418446007 hasConceptScore W2418446007C104317684 @default.
- W2418446007 hasConceptScore W2418446007C138626823 @default.
- W2418446007 hasConceptScore W2418446007C16685009 @default.
- W2418446007 hasConceptScore W2418446007C196843134 @default.
- W2418446007 hasConceptScore W2418446007C2777542201 @default.
- W2418446007 hasConceptScore W2418446007C2778805741 @default.
- W2418446007 hasConceptScore W2418446007C2780458022 @default.
- W2418446007 hasConceptScore W2418446007C2781087480 @default.
- W2418446007 hasConceptScore W2418446007C30481170 @default.
- W2418446007 hasConceptScore W2418446007C53226629 @default.
- W2418446007 hasConceptScore W2418446007C54355233 @default.
- W2418446007 hasConceptScore W2418446007C71924100 @default.
- W2418446007 hasConceptScore W2418446007C86803240 @default.
- W2418446007 hasIssue "6" @default.
- W2418446007 hasLocation W24184460071 @default.
- W2418446007 hasLocation W24184460072 @default.
- W2418446007 hasOpenAccess W2418446007 @default.
- W2418446007 hasPrimaryLocation W24184460071 @default.
- W2418446007 hasRelatedWork W1976969499 @default.
- W2418446007 hasRelatedWork W1988405328 @default.
- W2418446007 hasRelatedWork W2033075770 @default.
- W2418446007 hasRelatedWork W2041210821 @default.
- W2418446007 hasRelatedWork W2059302068 @default.
- W2418446007 hasRelatedWork W2071534761 @default.
- W2418446007 hasRelatedWork W2094694074 @default.
- W2418446007 hasRelatedWork W2101406350 @default.
- W2418446007 hasRelatedWork W2155279304 @default.
- W2418446007 hasRelatedWork W2163346379 @default.
- W2418446007 hasRelatedWork W2362854615 @default.
- W2418446007 hasRelatedWork W2366480888 @default.
- W2418446007 hasRelatedWork W2370440353 @default.
- W2418446007 hasRelatedWork W2373457546 @default.
- W2418446007 hasRelatedWork W2387980665 @default.
- W2418446007 hasRelatedWork W2399003691 @default.
- W2418446007 hasRelatedWork W246835991 @default.
- W2418446007 hasRelatedWork W2907605925 @default.
- W2418446007 hasRelatedWork W3141327811 @default.
- W2418446007 hasRelatedWork W3150771345 @default.
- W2418446007 hasVolume "44" @default.
- W2418446007 isParatext "false" @default.
- W2418446007 isRetracted "false" @default.
- W2418446007 magId "2418446007" @default.
- W2418446007 workType "article" @default.