Matches in SemOpenAlex for { <https://semopenalex.org/work/W2418469240> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2418469240 endingPage "12" @default.
- W2418469240 startingPage "1005" @default.
- W2418469240 abstract "Human colon carcinoma cells were treated with non-toxic levels of sodium butyrate, retinoic acid or phorbol ester, eliciting characteristic growth inhibition and morphological changes. Since protein-carbohydrate interactions are supposedly involved in regulatory processes and can serve within targeted drug delivery, the capacity to bind components of the carbohydrate chains of cellular glycoconjugates was monitored for such cells in relation to the type of the medium additive. The pattern of binding of a panel of neoglycoproteins was significantly altered for fixed cells, depending on the type of putative maturation factor. Quantitation of cell surface sugar receptors at a non-saturating concentration of neoglycoenzyme, employed as carbohydrate ligand-exposing probe, led to a similar conclusion. Up to six-fold increases were determined for individual probes. Binding studies with varying concentrations of neoglycoenzymes in the case of four ligands revealed that the receptor density, but not the affinity was significantly affected. Biochemical analyses corroborated this result by demonstrating mainly quantitative differences after affinity chromatography of detergent extracts from the four types of cell pellet. By showing the inhibitory potency of neoglycoprotein-conjugated liposomes in the cell binding assay with neoglycoenzymes, a perspective is indicated, of how the different effects of the differentiation-inducing agents might be beneficially exploited in targeted drug delivery." @default.
- W2418469240 created "2016-06-24" @default.
- W2418469240 creator A5001261510 @default.
- W2418469240 creator A5061586215 @default.
- W2418469240 creator A5068822887 @default.
- W2418469240 creator A5077361354 @default.
- W2418469240 date "1990-07-01" @default.
- W2418469240 modified "2023-10-17" @default.
- W2418469240 title "Regulation of distribution, amount and ligand affinity of sugar receptors in human colon carcinoma cells by treatment with sodium butyrate, retinoic acid and phorbol ester." @default.
- W2418469240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2382971" @default.
- W2418469240 hasPublicationYear "1990" @default.
- W2418469240 type Work @default.
- W2418469240 sameAs 2418469240 @default.
- W2418469240 citedByCount "12" @default.
- W2418469240 crossrefType "journal-article" @default.
- W2418469240 hasAuthorship W2418469240A5001261510 @default.
- W2418469240 hasAuthorship W2418469240A5061586215 @default.
- W2418469240 hasAuthorship W2418469240A5068822887 @default.
- W2418469240 hasAuthorship W2418469240A5077361354 @default.
- W2418469240 hasConcept C100544194 @default.
- W2418469240 hasConcept C104317684 @default.
- W2418469240 hasConcept C116569031 @default.
- W2418469240 hasConcept C13426554 @default.
- W2418469240 hasConcept C170493617 @default.
- W2418469240 hasConcept C185592680 @default.
- W2418469240 hasConcept C195794163 @default.
- W2418469240 hasConcept C2776979534 @default.
- W2418469240 hasConcept C2778942008 @default.
- W2418469240 hasConcept C2780043322 @default.
- W2418469240 hasConcept C2780758401 @default.
- W2418469240 hasConcept C2781121885 @default.
- W2418469240 hasConcept C54355233 @default.
- W2418469240 hasConcept C55493867 @default.
- W2418469240 hasConcept C62478195 @default.
- W2418469240 hasConcept C81885089 @default.
- W2418469240 hasConcept C86803240 @default.
- W2418469240 hasConceptScore W2418469240C100544194 @default.
- W2418469240 hasConceptScore W2418469240C104317684 @default.
- W2418469240 hasConceptScore W2418469240C116569031 @default.
- W2418469240 hasConceptScore W2418469240C13426554 @default.
- W2418469240 hasConceptScore W2418469240C170493617 @default.
- W2418469240 hasConceptScore W2418469240C185592680 @default.
- W2418469240 hasConceptScore W2418469240C195794163 @default.
- W2418469240 hasConceptScore W2418469240C2776979534 @default.
- W2418469240 hasConceptScore W2418469240C2778942008 @default.
- W2418469240 hasConceptScore W2418469240C2780043322 @default.
- W2418469240 hasConceptScore W2418469240C2780758401 @default.
- W2418469240 hasConceptScore W2418469240C2781121885 @default.
- W2418469240 hasConceptScore W2418469240C54355233 @default.
- W2418469240 hasConceptScore W2418469240C55493867 @default.
- W2418469240 hasConceptScore W2418469240C62478195 @default.
- W2418469240 hasConceptScore W2418469240C81885089 @default.
- W2418469240 hasConceptScore W2418469240C86803240 @default.
- W2418469240 hasIssue "4" @default.
- W2418469240 hasLocation W24184692401 @default.
- W2418469240 hasOpenAccess W2418469240 @default.
- W2418469240 hasPrimaryLocation W24184692401 @default.
- W2418469240 hasRelatedWork W1608704672 @default.
- W2418469240 hasRelatedWork W177763350 @default.
- W2418469240 hasRelatedWork W1970745645 @default.
- W2418469240 hasRelatedWork W1987486890 @default.
- W2418469240 hasRelatedWork W2065573626 @default.
- W2418469240 hasRelatedWork W2073872223 @default.
- W2418469240 hasRelatedWork W2127512892 @default.
- W2418469240 hasRelatedWork W2393246256 @default.
- W2418469240 hasRelatedWork W2401320033 @default.
- W2418469240 hasRelatedWork W2418469240 @default.
- W2418469240 hasVolume "10" @default.
- W2418469240 isParatext "false" @default.
- W2418469240 isRetracted "false" @default.
- W2418469240 magId "2418469240" @default.
- W2418469240 workType "article" @default.