FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2418472672> ?p ?o ?g. }

• W2418472672 abstract "The aggressiveness of pancreatic ductal adenocarcinoma (PDAC) is highly dependent on the level of differentiation and the composition of the stroma. In this preclinical study, we investigated the potential of diffusion-weighted magnetic resonance imaging (DW-MRI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as noninvasive methods for providing information on the differentiation and the stroma of PDACs.Xenografted tumors initiated from four PDAC cell lines (BxPC-3, Capan-2, MIAPaCa-2, and Panc-1) were included in the study. DW-MRI and DCE-MRI were carried out on a 7.05-T MR scanner, and tumor images of ADC (the apparent diffusion coefficient), K (trans) (the volume transfer constant of Gd-DOTA), and v e (the fractional distribution volume of Gd-DOTA) were produced. The level of differentiation and the amount and structure of collagen I and collagen IV were determined by examining histological preparations.Differentiated tumors showed lower levels of collagen I and collagen IV than non-differentiated tumors. Significant correlations were found between ADC and v e, and both parameters differentiated clearly between collagen-rich non-differentiated tumors and differentiated tumors containing less collagen.Differentiated PDAC xenografts show higher ADC values and higher v e values than their non-differentiated counterparts. This observation supports the application of parametric MR images as tumor biomarkers in PDAC. Patients showing low values of ADC and v e most likely have non-differentiated tumors with extensive stroma and, hence, poor prognosis." @default.
• W2418472672 created "2016-06-24" @default.
• W2418472672 creator A5000402355 @default.
• W2418472672 creator A5002521506 @default.
• W2418472672 creator A5021640681 @default.
• W2418472672 creator A5068066992 @default.
• W2418472672 creator A5084401735 @default.
• W2418472672 date "2016-06-07" @default.
• W2418472672 modified "2023-10-13" @default.
• W2418472672 title "Diffusion-weighted and dynamic contrast-enhanced MRI of pancreatic adenocarcinoma xenografts: associations with tumor differentiation and collagen content" @default.
• W2418472672 cites W1501281998 @default.
• W2418472672 cites W1510384544 @default.
• W2418472672 cites W1569222029 @default.
• W2418472672 cites W1676308325 @default.
• W2418472672 cites W1828047435 @default.
• W2418472672 cites W1946441967 @default.
• W2418472672 cites W1966713611 @default.
• W2418472672 cites W1973986953 @default.
• W2418472672 cites W1974263994 @default.
• W2418472672 cites W1992792031 @default.
• W2418472672 cites W1994911227 @default.
• W2418472672 cites W2001974555 @default.
• W2418472672 cites W2018737825 @default.
• W2418472672 cites W2020189113 @default.
• W2418472672 cites W2020481638 @default.
• W2418472672 cites W2021883439 @default.
• W2418472672 cites W2030577010 @default.
• W2418472672 cites W2042098439 @default.
• W2418472672 cites W2045104836 @default.
• W2418472672 cites W2045462226 @default.
• W2418472672 cites W2061286840 @default.
• W2418472672 cites W2063070663 @default.
• W2418472672 cites W2069882413 @default.
• W2418472672 cites W2072626310 @default.
• W2418472672 cites W2076921551 @default.
• W2418472672 cites W2084532490 @default.
• W2418472672 cites W2088812649 @default.
• W2418472672 cites W2099322193 @default.
• W2418472672 cites W2102022634 @default.
• W2418472672 cites W2103510102 @default.
• W2418472672 cites W2107441200 @default.
• W2418472672 cites W2110796306 @default.
• W2418472672 cites W2118736534 @default.
• W2418472672 cites W2119716977 @default.
• W2418472672 cites W2141683493 @default.
• W2418472672 cites W2168992025 @default.
• W2418472672 cites W2171902319 @default.
• W2418472672 cites W2202323636 @default.
• W2418472672 cites W2323063920 @default.
• W2418472672 doi "https://doi.org/10.1186/s12967-016-0920-y" @default.
• W2418472672 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4897888" @default.
• W2418472672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27268062" @default.
• W2418472672 hasPublicationYear "2016" @default.
• W2418472672 type Work @default.
• W2418472672 sameAs 2418472672 @default.
• W2418472672 citedByCount "34" @default.
• W2418472672 countsByYear W24184726722017 @default.
• W2418472672 countsByYear W24184726722018 @default.
• W2418472672 countsByYear W24184726722019 @default.
• W2418472672 countsByYear W24184726722020 @default.
• W2418472672 countsByYear W24184726722021 @default.
• W2418472672 countsByYear W24184726722022 @default.
• W2418472672 countsByYear W24184726722023 @default.
• W2418472672 crossrefType "journal-article" @default.
• W2418472672 hasAuthorship W2418472672A5000402355 @default.
• W2418472672 hasAuthorship W2418472672A5002521506 @default.
• W2418472672 hasAuthorship W2418472672A5021640681 @default.
• W2418472672 hasAuthorship W2418472672A5068066992 @default.
• W2418472672 hasAuthorship W2418472672A5084401735 @default.
• W2418472672 hasBestOaLocation W24184726721 @default.
• W2418472672 hasConcept C121608353 @default.
• W2418472672 hasConcept C126322002 @default.
• W2418472672 hasConcept C126838900 @default.
• W2418472672 hasConcept C142724271 @default.
• W2418472672 hasConcept C143409427 @default.
• W2418472672 hasConcept C149550507 @default.
• W2418472672 hasConcept C185592680 @default.
• W2418472672 hasConcept C204232928 @default.
• W2418472672 hasConcept C2777996000 @default.
• W2418472672 hasConcept C2780210213 @default.
• W2418472672 hasConcept C2781182431 @default.
• W2418472672 hasConcept C502942594 @default.
• W2418472672 hasConcept C52124034 @default.
• W2418472672 hasConcept C70816921 @default.
• W2418472672 hasConcept C71924100 @default.
• W2418472672 hasConceptScore W2418472672C121608353 @default.
• W2418472672 hasConceptScore W2418472672C126322002 @default.
• W2418472672 hasConceptScore W2418472672C126838900 @default.
• W2418472672 hasConceptScore W2418472672C142724271 @default.
• W2418472672 hasConceptScore W2418472672C143409427 @default.
• W2418472672 hasConceptScore W2418472672C149550507 @default.
• W2418472672 hasConceptScore W2418472672C185592680 @default.
• W2418472672 hasConceptScore W2418472672C204232928 @default.
• W2418472672 hasConceptScore W2418472672C2777996000 @default.
• W2418472672 hasConceptScore W2418472672C2780210213 @default.
• W2418472672 hasConceptScore W2418472672C2781182431 @default.
• W2418472672 hasConceptScore W2418472672C502942594 @default.
• W2418472672 hasConceptScore W2418472672C52124034 @default.
• W2418472672 hasConceptScore W2418472672C70816921 @default.
• W2418472672 hasConceptScore W2418472672C71924100 @default.

• next