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- W2418482242 abstract "Biochemical modulation of 5-FU by leucovorin (LV) has been demonstrated to increase the therapeutic effect compared to single agent 5-FU in the treatment of patients (pts) with advanced colorectal cancer. The purpose of this study was to determine the effectiveness of the 5-FU + LV combination as adjuvant therapy following surgery in pts with Dukes' B, C colon cancer. Pts were entered in a stratified clinical trial comparing two different combination chemotherapeutic regimens to single agent 5-FU, given orally as a control. This report summarized the result of treatment in 61 pts who were 5-FU oral alone and 32 pts who were 5-FU (375 mg/m2) and low-dose LV (20 mg/m2) intravenously for 5 days with 5-FU oral intake. 5-FU with LV regimen was associated with an improved survival compared with the single agent 5-FU oral intake (p < 0.05). 5-FU with LV regimen resulted in less recurrence in liver and lung compared with single-agent 5-FU oral intake." @default.
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- W2418482242 date "1998-07-01" @default.
- W2418482242 modified "2023-09-23" @default.
- W2418482242 title "[5-fluorouracil and low-dose leucovorin as surgical adjuvant therapy from viewpoint of long-term outcome]." @default.
- W2418482242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9679580" @default.
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