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- W2418550367 abstract "A γ-carbon activation method that operates through N-heterocyclic carbene/Brønsted acid cooperative catalysis for highly enantioselective synthesis of δ-lactams is reported. The protocol allows the challenging remote γ-carbon control of regioselectivity and enantioselectivity through introduction of an appropriate γ-leaving group in the enals. The reaction offers good yields and excellent enantioselectivities, and the resulting cyclic products can be easily converted into high-value drug-like derivatives." @default.
- W2418550367 created "2016-06-24" @default.
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- W2418550367 date "2015-07-27" @default.
- W2418550367 modified "2023-10-16" @default.
- W2418550367 title "γ-Carbon Activation through N-Heterocyclic Carbene/Brønsted Acids Cooperative Catalysis: A Highly Enantioselective Route to δ-Lactams" @default.
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- W2418550367 doi "https://doi.org/10.1021/acs.orglett.5b01827" @default.
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