Matches in SemOpenAlex for { <https://semopenalex.org/work/W2418589037> ?p ?o ?g. }
- W2418589037 endingPage "e188" @default.
- W2418589037 startingPage "e188" @default.
- W2418589037 abstract "Abstract The metabolic features of tumor cells diverge from those of normal cells. Otto Warburg was the first to observe that cancer cells dramatically increase their glucose consumption to generate ATP. He also claimed that cancer cells do not have functional mitochondria or oxidative phosphorylation (OXPHOS) but simply rely on glycolysis to provide ATP to the cell, even in the presence of oxygen (aerobic glycolysis). Several studies have revisited this observation and demonstrated that most cancer cells contain metabolically efficient mitochondria. Indeed, to sustain high proliferation rates, cancer cells require functional mitochondria to provide ATP and intermediate metabolites, such as citrate and cofactors, for anabolic reactions. This difference in metabolism between normal and tumors cells causes the latter to be more sensitive to agents that can disrupt energy homeostasis. In this review, we focus on energy disruptors, such as biguanides, 2-deoxyglucose and 5-aminoimidazole-4-carboxamide ribonucleotide, that interfere with the main metabolic pathways of the cells, OXPHOS, glycolysis and glutamine metabolism. We discuss the preclinical data and the mechanisms of action of these disruptors at the cellular and molecular levels. Finally, we consider whether these drugs can reasonably contribute to the antitumoral therapeutic arsenal in the future." @default.
- W2418589037 created "2016-06-24" @default.
- W2418589037 creator A5010561641 @default.
- W2418589037 creator A5012934683 @default.
- W2418589037 creator A5055039013 @default.
- W2418589037 creator A5070668061 @default.
- W2418589037 date "2016-01-18" @default.
- W2418589037 modified "2023-10-11" @default.
- W2418589037 title "Energy disruptors: rising stars in anticancer therapy?" @default.
- W2418589037 cites W126783609 @default.
- W2418589037 cites W1482720457 @default.
- W2418589037 cites W1702423934 @default.
- W2418589037 cites W1892036645 @default.
- W2418589037 cites W1971597300 @default.
- W2418589037 cites W1982789056 @default.
- W2418589037 cites W1987334928 @default.
- W2418589037 cites W1988943434 @default.
- W2418589037 cites W1994504180 @default.
- W2418589037 cites W1995069275 @default.
- W2418589037 cites W1997003352 @default.
- W2418589037 cites W1997086634 @default.
- W2418589037 cites W1997625666 @default.
- W2418589037 cites W1997909566 @default.
- W2418589037 cites W1998707180 @default.
- W2418589037 cites W1998771362 @default.
- W2418589037 cites W2010728263 @default.
- W2418589037 cites W2011185738 @default.
- W2418589037 cites W2012442095 @default.
- W2418589037 cites W2014880757 @default.
- W2418589037 cites W2016310489 @default.
- W2418589037 cites W2019480457 @default.
- W2418589037 cites W2022899908 @default.
- W2418589037 cites W2023947368 @default.
- W2418589037 cites W2026967508 @default.
- W2418589037 cites W2027442494 @default.
- W2418589037 cites W2028005041 @default.
- W2418589037 cites W2028268047 @default.
- W2418589037 cites W2030031350 @default.
- W2418589037 cites W2037177985 @default.
- W2418589037 cites W2037546085 @default.
- W2418589037 cites W2038227076 @default.
- W2418589037 cites W2039212784 @default.
- W2418589037 cites W2043365422 @default.
- W2418589037 cites W2043376395 @default.
- W2418589037 cites W2052240811 @default.
- W2418589037 cites W2052498320 @default.
- W2418589037 cites W2053495637 @default.
- W2418589037 cites W2061075485 @default.
- W2418589037 cites W2064656431 @default.
- W2418589037 cites W2067156757 @default.
- W2418589037 cites W2067680768 @default.
- W2418589037 cites W2072154569 @default.
- W2418589037 cites W2072270661 @default.
- W2418589037 cites W2072451938 @default.
- W2418589037 cites W2078190084 @default.
- W2418589037 cites W2079158452 @default.
- W2418589037 cites W2082705146 @default.
- W2418589037 cites W2085516015 @default.
- W2418589037 cites W2089983743 @default.
- W2418589037 cites W2092340120 @default.
- W2418589037 cites W2093154482 @default.
- W2418589037 cites W2093664485 @default.
- W2418589037 cites W2102341833 @default.
- W2418589037 cites W2104696999 @default.
- W2418589037 cites W2105561184 @default.
- W2418589037 cites W2114147584 @default.
- W2418589037 cites W2117830992 @default.
- W2418589037 cites W2118637676 @default.
- W2418589037 cites W2119437574 @default.
- W2418589037 cites W2121727754 @default.
- W2418589037 cites W2123014930 @default.
- W2418589037 cites W2125292576 @default.
- W2418589037 cites W2125747634 @default.
- W2418589037 cites W2126701448 @default.
- W2418589037 cites W2128123076 @default.
- W2418589037 cites W2129433069 @default.
- W2418589037 cites W2134907909 @default.
- W2418589037 cites W2138226825 @default.
- W2418589037 cites W2138791124 @default.
- W2418589037 cites W2146780639 @default.
- W2418589037 cites W2147190181 @default.
- W2418589037 cites W2150377102 @default.
- W2418589037 cites W2152561870 @default.
- W2418589037 cites W2154472706 @default.
- W2418589037 cites W2157655280 @default.
- W2418589037 cites W2158076290 @default.
- W2418589037 cites W2158240289 @default.
- W2418589037 cites W2158955581 @default.
- W2418589037 cites W2159620999 @default.
- W2418589037 cites W2160103929 @default.
- W2418589037 cites W2160571820 @default.
- W2418589037 cites W2161735692 @default.
- W2418589037 cites W2164882663 @default.
- W2418589037 cites W2166393423 @default.
- W2418589037 cites W2167195670 @default.
- W2418589037 cites W2168576472 @default.
- W2418589037 cites W2409153565 @default.
- W2418589037 cites W923441199 @default.