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- W2418639157 abstract "Cataracts were induced in young rats by feeding a semi-purified diet containing l-amino acids as the primary source of nitrogen and a quantity of tryptophan sufficient only to allow slight but constant weight gain. Tryptophan was thereby isolated as the sole limiting nutrient without accompanying general malnutrition.After three or seven weeks, low-tryptophan intake retarded lens growth by 20–40% but concentration and distribution of lens proteins were comparable to pair-fed or ad libitum-fed controls. Between the seventh and ninth week 80% of the low tryptophan-fed animals developed cataract concurrent with a 33% increase in lens wet weight, a 22% increase in insoluble protein, and a disappearance of the BH-crystallins. The data suggest that this cataract may not be a consequence of diminished crystallin synthesis as has been previously proposed." @default.
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- W2418639157 date "1975-02-01" @default.
- W2418639157 modified "2023-09-26" @default.
- W2418639157 title "Experimental cataracts induced by a tryptophan-free diet" @default.
- W2418639157 doi "https://doi.org/10.1016/0014-4835(75)90174-8" @default.
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