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• W2418719108 abstract "Background: Despite relative fewer and smaller studies addressing the occurrence of depressive symptoms in atypical parkinsonian (aPD) patients, depression appears to be more frequent than in Parkinson’s disease (PD) patients. This study aimed to estimate the incidence of depressive symptoms in parkinsonian patients. Methods: We identified a retrospective cohort of aPD patients (MSA, PSP, CBD, and DLB) and age-gender matched PD controls that participated in the UF-INFORM database from 2007-2015. Depressive symptoms at initial and subsequent encounters were evaluated using the Beck Depression Inventory (BDI). Subjects without depression (BDI ≤13) at initial encounter were followed longitudinally and assessed for depressive symptoms. Incidence rate and Kaplan-Meier estimates of cumulative incidence of depressive symptoms were determined across the different groups. Results: We identified 69 CBS, 60 DLB, 130 MSA, 102 PSP, and 2352 PD subjects without depressive symptoms at initial encounter. Among this cohort, incident rate of depressive symptoms (BDI >13) was 13.7 per 100 person-years for PD and 16.6 for aPD subgroups (MSA: 21.9, CBS: 27.1, DLB: 26.5, PSP: 52.8). One-minus survival curves demonstrated statistically significant (<0.001) differences between different subgroups, and a multiple logistic Cox regression showed significantly higher hazard ratios between DLB (HR 4.08, CI 1.19-13.98, p = 0.02) and PSP (HR 3.32, CI 95[percnt] 1.28 - 8.56, p = 0.01) when compared to PD. Conclusions: In parkinsonian patients without depression at baseline, there is a particularly high subsequent incidence of depression in PSP and DLB patients than those with PD. These findings emphasize the importance of longitudinal screening for depression in parkinsonian patients even when there are no mood concerns at baseline, particularly as studies in parkinsonism frequently link depression and QoL Disclosure: Dr. Almeida has nothing to disclose. Dr. Ahmed has nothing to disclose. Dr. Walz has nothing to disclose. Dr. De Jesus has nothing to disclose. Dr. Patterson has nothing to disclose. Dr. Martinez-Ramirez has nothing to disclose. Dr. Vaillancourt has received research support from NIH, Michael J. Fox Foundation, Bachmann-Strauss Foundation, Tyler9s Hope Foundation, and UT Southwestern Medical Center. Dr. Bowers has nothing to disclose. Dr. Ward has nothing to disclose. Dr. Okun has received royalty payments from Demos, Humana, Amazon, Smashwords, Books4Patients, and Cambridge. Dr. Okun has received research support from the Michael J. Fox Foundation, the National Parkinson Foundation, the Parkinson Alliance, the Smallwo Dr. Armstrong has received personal compensation from the American Academy of Neurology as a consultant. Dr. Armstrong has received research support from Abbvie, the Parkinson Study Group (PSG), the Huntington Study Group (HSG), and CHDI Foundation, Inc. Dr. McFarland has nothing to disclose." @default.
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• W2418719108 date "2016-04-05" @default.
• W2418719108 modified "2023-10-18" @default.
• W2418719108 title "Greater Incidence of Depressive Symptoms in Atypical Parkinsonism: Importance of Early Screening (S19.005)" @default.
• W2418719108 hasPublicationYear "2016" @default.
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