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• W2418782857 endingPage "2138" @default.
• W2418782857 startingPage "2132" @default.
• W2418782857 abstract "Translocations involving chromosome 8 at band q24 and one of the Ig loci on chromosomes 14q32, 22q11, and 2p11 are the hallmark of Burkitt's lymphoma (BL). It has been previously observed that the exact localization of the breakpoints at chromosome 8q24 can vary significantly from patient to patient, scattering over a distance of more than 300 kb upstream of c-myc and about 300 kb downstream of c-myc. To generate probes for fluorescence in situ hybridization (FISH) that detect most c-myc translocations, we screened a yeast artificial chromosome (YAC) library from normal human lymphocytes by colony hybridization, using three markers surrounding the c-myc gene as probes. We obtained 10 YAC clones ranging in size between 500 and 200 kb. Two nonchimeric clones were used for FISH on several BL cell lines and patient samples with different breakpoints at 8q24. Our results show that the YAC clones detected translocations scattered along approximately 200 kb in both metaphase chromosomes and interphase nuclei. The sensitivity, rapidity, and feasibility in nondividing cells render FISH an important diagnostic tool. Furthermore, the use of large DNA fragments such as YACs greatly simplifies the detection of translocations with widely scattered breakpoints such as these seen in BL." @default.
• W2418782857 created "2016-06-24" @default.
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• W2418782857 date "1995-04-15" @default.
• W2418782857 modified "2023-10-10" @default.
• W2418782857 title "Detection of myc translocations in lymphoma cells by fluorescence in situ hybridization with yeast artificial chromosomes" @default.
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• W2418782857 doi "https://doi.org/10.1182/blood.v85.8.2132.bloodjournal8582132" @default.
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