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- W2418805995 abstract "Proc Amer Assoc Cancer Res, Volume 45, 20041160 Cancer diagnostics and therapeutics are often based on clinically relevant markers that are expressed specifically in a malignant tissue and at a very low or undetectable level in normal tissue. This study examines potential markers for papillary thyroid carcinoma (PTC) using a human 4000-gene cDNA microarray to monitor PTC-specific gene expression of thyroid-specific genes, thyroglobulin, thyroid peroxidase, and thyroid-stimulating hormone receptor. Gene expression profiles for PTC tissue, normal thyroid tissue, and healthy peripheral blood cells were compared. Sixty-four genes were overexpressed in PTC tissue relative to normal thyroid tissue and healthy peripheral blood cells. The genes that were up-regulated in PTC were involved in cell cycle regulation, DNA damage response, angiogenesis, and oncogenesis. Among these genes, basic fibroblast growth factor and platelet-derived growth factor were identified by immunochemical methods as proteins that are specifically expressed at high levels in thyroid neoplasms. In this study, basic fibroblast growth factor, which has been identified as a biomarker for PTC, was overexpressed in 54% of PTC cases 67% of follicular carcinomas, and 36% of benign thyroid neoplasms. Platelet-derived growth factor was overexpressed in 81% of PTC cases and 100% of follicular carcinomas, but was immunonegative in normal thyroid tissues and benign thyroid neoplasms. These results suggest that platelet-derived growth factor may be a potential biomarker for PTC and follicular carcinoma. This study demonstrates that expression profile analysis using a microarray followed by an immunohistochemical study can be used to facilitate the development of molecular biomarkers for cancer." @default.
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- W2418805995 date "2004-04-01" @default.
- W2418805995 modified "2023-09-25" @default.
- W2418805995 title "Gene expression profiling identifies platelet-derived growth factor as a diagnostic molecular marker for papillary thyroid carcinoma" @default.
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