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• W2418935478 abstract "Abstract The morphological diversity of insects is important for their survival; in essence, it results from the differential expression of genes during development of the insect body. The silkworm apodal ( ap ) mutant has degraded thoracic legs making crawling and eating difficult and the female is sterile, which is an ideal subject for studying the molecular mechanisms of morphogenesis. Here, we confirmed that the infertility of ap female moths is a result of the degradation of the bursa copulatrix. Positional cloning of ap locus and expression analyses reveal that the Bombyx mori sister of odd and bowl ( Bmsob ) gene is a strong candidate for the ap mutant. The expression of Bmsob is down-regulated, while the corresponding Hox genes are up-regulated in the ap mutant compared to the wild type. Analyses with the dual luciferase assay present a declined activity of the Bmsob promoter in the ap mutant. Furthermore, we demonstrate that Bmsob can inhibit Hox gene expression directly and by suppressing the expression of other genes, including the BmDsp gene. The results of this study are an important contribution to our understanding of the diversification of insect body plan." @default.
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• W2418935478 date "2016-01-07" @default.
• W2418935478 modified "2023-10-01" @default.
• W2418935478 title "Molecular mapping and characterization of the silkworm apodal mutant" @default.
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• W2418935478 doi "https://doi.org/10.1038/srep18956" @default.
• W2418935478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4704060" @default.
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• W2418935478 hasPublicationYear "2016" @default.
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