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• W2418981305 abstract "G. H. VAN ~rALS and P. EMMELOT (Eingegangen am 28. Februar 1957) It was concluded from previous work 1 that the synthesis of longchain fatty acids in tumor slices might be related to the glycolytie pathway. In those experiments addition of unlabeled glucose markedly enhanced lipogenesis* from aeetate-l-C 1~ without appreciably affecting the appearance of isotope in the respiratory carbon dioxide. Cholesterogenesis* was stimulated less than lipogenesis in the presence of carbohydrate. In order to study the possible relations between these metabolic processes further, use has been made in the present experiments of anaerobic conditions and of the metabolic inhibitors malonate, monoiodoacetate (MIA), 2,4-dinitropheno l (2,4-DNP) and methylene blue (MB). The effect of the inhibitors on the oxidation of glucose-i- and -6-C 14 has also been investigated. Slices of spontaneous and transplanted mouse and rat tumors and in a few eases aseites tumor cells have been used. Experimental Methods Sodium acetate-l-C z4 was synthesized by carbonation of methyl magnesium iodide in 98% yield. BaC140a, uniformly labeled glucose (glueose-u-C t4) and glucose-1-C 14 were purchased from the Radioehemical Centre, Amersham (England). Glucose-6-C 14 was obtained from the National Bureau of Standards, Washington, on allocation of the Atomic Energy Commission. Carbon dioxide, protein-bound amble acids, the digitonin-precipitable steroid fraction and long-chain fatty acids were isolated as described '2 and assayed for radioactivity. The numerical values which are listed in the tables represent the incorporation of tracer from the C14-acetate into the particular compounds after incubation under special conditions (anaerobically, in the presence of malonate, etc.) as per cent of the incorporation found under standard conditions. The latter values were obtained from samples isolated from I gm fresh weight of tumor slices which had been incubated with 2,5 mg sodium acetate-l-C 1~ (5  105 cpm as an * To facilitate description the terms lipogenesis and eholesterogenesis will be used to indicate the incorporation of C ~t into the long-chain fatty acids and into the digitonin-precipitable steroid fraction (cholesterol), respectively." @default.
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• W2418981305 date "1957-01-01" @default.
• W2418981305 modified "2023-09-23" @default.
• W2418981305 title "The metabolism of neoplastic tissues The effect of some metabolic inhibitors on the synthesis of cholesterol and long-chain fatty acids by tumor tissues in vitro" @default.
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