Matches in SemOpenAlex for { <https://semopenalex.org/work/W2418999849> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2418999849 endingPage "305" @default.
- W2418999849 startingPage "4299" @default.
- W2418999849 abstract "Genetic alterations of p14ARF contribute to dysfunction of p53 pathways by disruption of MDM2-mediated inhibition of p53. P14(ARF) was investigated by focusing on the homozygous deletion (HD) in the INK4a/ARF locus and hypermethylation of the p14(ARF) promoter in renal cell cancer (RCC).Using 6 RCC cell lines, RT-PCR and Western blotting was performed for p14(ARF). DNA from 34 RCCs was analyzed for HD in the INK4a/ARF locus, promoter hypermethylation and p53 gene mutation.HD was confirmed in 4 out of 6 cell lines and in 8 out of 34 (23.5%) RCC specimens, which correlated with the presence of metastasis, high tumor grade and had a tendency to more advanced stage (I vs. II-IV). No hypermethylation of the p14(ARF) promoter or p53 mutation was detected among the RCC specimens.These results indicate that the deletion in the INK4a/ARF locus might contribute to tumor progression in RCC at least partly by functional inactivation of wild-type p53." @default.
- W2418999849 created "2016-06-24" @default.
- W2418999849 creator A5007596741 @default.
- W2418999849 creator A5015451902 @default.
- W2418999849 creator A5067955573 @default.
- W2418999849 creator A5069838591 @default.
- W2418999849 creator A5070194034 @default.
- W2418999849 date "2007-01-05" @default.
- W2418999849 modified "2023-09-23" @default.
- W2418999849 title "Homozygous deletions of the INK4a/ARF locus in renal cell cancer." @default.
- W2418999849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17201148" @default.
- W2418999849 hasPublicationYear "2007" @default.
- W2418999849 type Work @default.
- W2418999849 sameAs 2418999849 @default.
- W2418999849 citedByCount "8" @default.
- W2418999849 countsByYear W24189998492012 @default.
- W2418999849 countsByYear W24189998492013 @default.
- W2418999849 countsByYear W24189998492016 @default.
- W2418999849 countsByYear W24189998492017 @default.
- W2418999849 countsByYear W24189998492018 @default.
- W2418999849 crossrefType "journal-article" @default.
- W2418999849 hasAuthorship W2418999849A5007596741 @default.
- W2418999849 hasAuthorship W2418999849A5015451902 @default.
- W2418999849 hasAuthorship W2418999849A5067955573 @default.
- W2418999849 hasAuthorship W2418999849A5069838591 @default.
- W2418999849 hasAuthorship W2418999849A5070194034 @default.
- W2418999849 hasConcept C101762097 @default.
- W2418999849 hasConcept C104317684 @default.
- W2418999849 hasConcept C121608353 @default.
- W2418999849 hasConcept C133307689 @default.
- W2418999849 hasConcept C150194340 @default.
- W2418999849 hasConcept C153911025 @default.
- W2418999849 hasConcept C190727270 @default.
- W2418999849 hasConcept C2776192174 @default.
- W2418999849 hasConcept C2778264664 @default.
- W2418999849 hasConcept C2779013556 @default.
- W2418999849 hasConcept C502942594 @default.
- W2418999849 hasConcept C54355233 @default.
- W2418999849 hasConcept C555283112 @default.
- W2418999849 hasConcept C84597430 @default.
- W2418999849 hasConcept C86803240 @default.
- W2418999849 hasConceptScore W2418999849C101762097 @default.
- W2418999849 hasConceptScore W2418999849C104317684 @default.
- W2418999849 hasConceptScore W2418999849C121608353 @default.
- W2418999849 hasConceptScore W2418999849C133307689 @default.
- W2418999849 hasConceptScore W2418999849C150194340 @default.
- W2418999849 hasConceptScore W2418999849C153911025 @default.
- W2418999849 hasConceptScore W2418999849C190727270 @default.
- W2418999849 hasConceptScore W2418999849C2776192174 @default.
- W2418999849 hasConceptScore W2418999849C2778264664 @default.
- W2418999849 hasConceptScore W2418999849C2779013556 @default.
- W2418999849 hasConceptScore W2418999849C502942594 @default.
- W2418999849 hasConceptScore W2418999849C54355233 @default.
- W2418999849 hasConceptScore W2418999849C555283112 @default.
- W2418999849 hasConceptScore W2418999849C84597430 @default.
- W2418999849 hasConceptScore W2418999849C86803240 @default.
- W2418999849 hasIssue "6B" @default.
- W2418999849 hasLocation W24189998491 @default.
- W2418999849 hasOpenAccess W2418999849 @default.
- W2418999849 hasPrimaryLocation W24189998491 @default.
- W2418999849 hasRelatedWork W1577855529 @default.
- W2418999849 hasRelatedWork W1686733339 @default.
- W2418999849 hasRelatedWork W1974138460 @default.
- W2418999849 hasRelatedWork W1975618272 @default.
- W2418999849 hasRelatedWork W1977031471 @default.
- W2418999849 hasRelatedWork W1978898029 @default.
- W2418999849 hasRelatedWork W1986533872 @default.
- W2418999849 hasRelatedWork W1994161503 @default.
- W2418999849 hasRelatedWork W2048795040 @default.
- W2418999849 hasRelatedWork W2059898418 @default.
- W2418999849 hasRelatedWork W2068415131 @default.
- W2418999849 hasRelatedWork W2071440441 @default.
- W2418999849 hasRelatedWork W2081512227 @default.
- W2418999849 hasRelatedWork W2112037656 @default.
- W2418999849 hasRelatedWork W2133098662 @default.
- W2418999849 hasRelatedWork W2304804958 @default.
- W2418999849 hasRelatedWork W2323659170 @default.
- W2418999849 hasRelatedWork W2348242404 @default.
- W2418999849 hasRelatedWork W2414101916 @default.
- W2418999849 hasRelatedWork W347974062 @default.
- W2418999849 hasVolume "26" @default.
- W2418999849 isParatext "false" @default.
- W2418999849 isRetracted "false" @default.
- W2418999849 magId "2418999849" @default.
- W2418999849 workType "article" @default.