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• W2419022866 abstract "No AccessJournal of Urology1 May 1986Effects of Pyruvate Salts, Pyruvic Acid, and Bicarbonate Salts in Preventing Experimental Oxalate Urolithiasis in Rats Yoshihide Ogawa, Kazumi Yamaguchi, Tohru Tanaka, and Makoto Morozumi Yoshihide OgawaYoshihide Ogawa More articles by this author , Kazumi YamaguchiKazumi Yamaguchi More articles by this author , Tohru TanakaTohru Tanaka More articles by this author , and Makoto MorozumiMakoto Morozumi More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)45974-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Sodium pyruvate, potassium pyruvate, pyruvic acid, sodium bicarbonate and potassium bicarbonate were added to a calcium-oxalate lithogenic diet (a glycolic-acid diet) in order to determine their effects in preventing lithogenicity. Male Wistar-strain rats who had been fed the glycolic-acid diet developed marked urinary calculi within four weeks. Rats in the sodium and potassium pyruvate groups had, however, almost no stones in the urinary system. Rats in the bicarbonate and pyruvic-acid groups showed slightly less effect than those in the pyruvate groups. Urinary oxalate excretion was high in all the groups during the experiment. The urinary oxalate concentration was relatively higher in the sodium-pyruvate group, and significantly higher in the potassium-pyruvate group, than in the glycolic-acid group. Urinary citrate excretion was high both in the pyruvate and bicarbonate groups; the urinary citrate concentration was, however, significantly higher in the pyruvate groups than in the bicarbonate groups at the fourth experimental week. The urinary calcium and magnesium concentrations were irrelevant to the diets administered. Therefore, it can be concluded that pyruvate salts inhibit urinary calculi formation, not by decreasing oxalate synthesis, but by increasing the urinary citrate concentration; bicarbonate salts work in the same manner, but a little less effectively. © 1986 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByOgawa Y, Yamaguchi K and Morozumi M (2018) Effects of Magnesium Salts in Preventing Experimental Oxalate Urolithiasis in RatsJournal of Urology, VOL. 144, NO. 2 Part 1, (385-389), Online publication date: 1-Aug-1990. Volume 135Issue 5May 1986Page: 1057-1060 Advertisement Copyright & Permissions© 1986 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Yoshihide Ogawa More articles by this author Kazumi Yamaguchi More articles by this author Tohru Tanaka More articles by this author Makoto Morozumi More articles by this author Expand All Advertisement PDF DownloadLoading ..." @default.
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• W2419022866 title "Effects of Pyruvate Salts, Pyruvic Acid, and Bicarbonate Salts in Preventing Experimental Oxalate Urolithiasis in Rats" @default.
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