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• W2419036138 abstract "The aim of this study was to evaluate the impact of polymorphisms in the EPHX1 (c.416A > G, c.337T > C) and CYP3A4*22 genes involved in carbamazepine (CBZ) metabolism and pharmacoresistance among 118 Tunisian patients with epilepsy under maintenance dose of CBZ. These genetic polymorphisms were analyzed by PCR-RFLP. Associations between plasma CBZ concentration, CBZ-E concentration, maintenance doses and metabolic ratio (CBZ-E:CBZ, CBZ-D:CBZ-E) were analyzed with each polymorphism. Both variants of EPHX1 c.416A > G and c.337T > C are significantly associated with higher metabolic ratio CBZ-E:CBZ and seem to decrease the activity of the epoxide hydrolase. The CYP3A4*22 variant allele is significantly associated with lower CBZ-D:CBZ-E ratio and seems also to be associated with less activity of the cytochrome. Our data suggest that certain polymorphisms of metabolizing enzyme genes could influence inter-individual variability of CBZ metabolism." @default.
• W2419036138 created "2016-06-24" @default.
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• W2419036138 date "2016-01-02" @default.
• W2419036138 modified "2023-10-18" @default.
• W2419036138 title "Effects of<i>EPHX1</i>and<i>CYP3A4*22</i>genetic polymorphisms on carbamazepine metabolism and drug response among Tunisian epileptic patients" @default.
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• W2419036138 doi "https://doi.org/10.3109/01677063.2016.1155571" @default.
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