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• W2419037532 abstract "No AccessJournal of Urology1 Jun 1986Flow Cytometry of Renal Oncocytoma: Common Occurrence of Deoxyribonucleic Acid Polyploidy and Aneuploidy Leslie M. Rainwater, George M. Farrow, and Michael M. Lieber Leslie M. RainwaterLeslie M. Rainwater More articles by this author , George M. FarrowGeorge M. Farrow More articles by this author , and Michael M. LieberMichael M. Lieber More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)46025-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Flow cytometry was performed on 51 typical specimens of renal oncocytoma. Nuclei were extracted from paraffin-embedded archival material and isolated nuclei were stained with propidium iodide. Of the 51 available tissue blocks 86 per cent were evaluable and 50 per cent of these samples showed a deoxyribonucleic acid (DNA) histogram that was approximately the same as normal renal parenchyma. Of the oncocytoma samples 39 per cent showed a marked increase (more than 10 per cent of the nuclei) in the tetraploid DNA peak, while 11 per cent showed a distinct DNA aneuploid peak. Among 21 evaluable grade 2 oncocytic renal tumors 33 per cent showed a normal DNA histogram, 43 per cent showed a marked increase in the DNA tetraploid peak and 24 per cent showed a DNA aneuploid peak. The common presence of polyploid nuclei containing double quantities of chromosomal DNA may correlate with the long-standing pathological observation that oncocytic tumors often contain a distinct population of large nuclei. Indeed, 86 per cent concurrence was seen between the detection of an abnormal DNA content by flow cytometry and the histopathological presence of large abnormal nuclei in these specimens. Since renal oncocytomas (grade 1 oncocytic tumors) rarely, if ever, metastasize and are relatively noninvasive locally, their markedly abnormal flow cytometry patterns are of considerable interest. Moreover, DNA polyploidy has not been identified previously in renal tumors. The biological significance and mechanism of DNA polyploidy, and the relationship of DNA polyploidy and DNA aneuploidy to the pathogenesis of oncocytic renal tumors require further laboratory investigation. The clinical use of flow cytometry to classify and to predict the behavior of renal tumors will be complicated, since renal oncocytomas commonly have polyploid and aneuploid DNA histograms © 1986 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byBrown J, Takahashi S, Alcaraz A, Borell T, Anderl K, Qian J, Persons D, Bostwick D, Lieber M and Jenkins R (2018) Fluorescence In Situ Hybridization Analysis of Renal Oncocytoma Reveals Frequent Loss of Chromosomes Y and 1Journal of Urology, VOL. 156, NO. 1, (31-35), Online publication date: 1-Jul-1996.Morra M and Das S (2018) Renal Oncocytoma: A Review of Histogenesis, Histopathology, Diagnosis and TreatmentJournal of Urology, VOL. 150, NO. 2 Part 1, (295-302), Online publication date: 1-Aug-1993.Licht M, Novick A, Tubbs R, Klein E, Levin H and Streem S (2018) Renal Oncocytoma: Clinical and Biological CorrelatesJournal of Urology, VOL. 150, NO. 5 Part 1, (1380-1383), Online publication date: 1-Nov-1993.Meloni A, Bridge J and Sandberg A (2018) Reviews on Chromosome Studies in Urological Tumors I. Renal TumorsJournal of Urology, VOL. 148, NO. 2 Part 1, (253-265), Online publication date: 1-Aug-1992.Jung W, Peters C, Mandell J, Vawter G and Retik A (2018) Flow Cytometric Evaluation of Multicystic Dysplastic KidneysJournal of Urology, VOL. 144, NO. 2 Part 2, (413-415), Online publication date: 1-Aug-1990.Brauch H, Tory K, Linehan W, Weaver D, Lovell M and Zbar B (2018) Molecular Analysis of the Short Arm of Chromosome 3 in Five Renal OncocytomasJournal of Urology, VOL. 143, NO. 3, (622-624), Online publication date: 1-Mar-1990.Carini M, Selli C, Barbanti G, Lapini A, Turini D and Costantini A (2018) Conservative Surgical Treatment of Renal Cell Carcinoma: Clinical Experience and Reappraisal of IndicationsJournal of Urology, VOL. 140, NO. 4, (725-730), Online publication date: 1-Oct-1988.Winkler H and Lieber M (2018) Primary Squamous Cell Carcinoma of the Male Urethra: Nuclear Deoxyribonucleic Acid Ploidy Studied by Flow CytometryJournal of Urology, VOL. 139, NO. 2, (298-303), Online publication date: 1-Feb-1988.Psihramis K, Cin P, Dretler S, Prout G and Sandberg A (2018) Further Evidence that Renal Oncocytoma has Malignant PotentialJournal of Urology, VOL. 139, NO. 3, (585-587), Online publication date: 1-Mar-1988.Skinner D (2018) Editorial CommentJournal of Urology, VOL. 140, NO. 4, (730-731), Online publication date: 1-Oct-1988.Rainwater L, Hosaka Y, Farrow G and Lieber M (2018) Well Differentiated Clear Cell Renal Carcinoma: Significance of Nuclear Deoxyribonucleic Acid Patterns Studied by Flow CytometryJournal of Urology, VOL. 137, NO. 1, (15-20), Online publication date: 1-Jan-1987.Murphy W (2018) Editorial CommentJournal of Urology, VOL. 137, NO. 1, (20-20), Online publication date: 1-Jan-1987.Lieber M (2018) Editorial CommentJournal of Urology, VOL. 136, NO. 4, (895-895), Online publication date: 1-Oct-1986. Volume 135Issue 6June 1986Page: 1167-1171 Advertisement Copyright & Permissions© 1986 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Leslie M. Rainwater More articles by this author George M. Farrow More articles by this author Michael M. Lieber More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2419037532 title "Flow Cytometry of Renal Oncocytoma: Common Occurrence of Deoxyribonucleic Acid Polyploidy and Aneuploidy" @default.
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