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• W2419114400 abstract "Primary neuroendocrine carcinomas (NEC) are rare tumors in children and young adults, resulting in a lack of standardized treatment approach. To refine the molecular taxonomy of these rare tumors, we performed whole exome sequencing in a pediatric patient with mediastinal NEC. We identified a somatic mutation in HRAS gene and LOH regions in NF2, MYO18B, and RUX3 genes. In addition, a germline heterozygous somatic variant in BRCA2 with LOH at that same position in the tumor tissue was also found. Our data provide valuable insight into the genomic landscape of this tumor, prompting further investigation of therapeutic targets." @default.
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• W2419114400 date "2016-01-01" @default.
• W2419114400 modified "2023-10-06" @default.
• W2419114400 title "Genomic Characterization of Poorly Differentiated Neuroendocrine Carcinoma in a Pediatric Patient" @default.
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• W2419114400 doi "https://doi.org/10.1097/mph.0000000000000463" @default.
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