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• W2419146114 abstract "< /B > Spinal cord injuries negatively affect the individuals and the life quality of their families due to neurological deficits caused by trauma. The prevalence of spinal cord injury is 15-45/1 million in the world. Caffeic acid phenethyl ester (CAPE) is the most active component of propolis and has neuroprotective, anti-oxidant and anti-apoptotic effects. Our aim was to determine the effects of CAPE on the prevention of secondary injury and to compare with methylprednisolone.Forty rats were divided into 4 groups. The control group did not undergo surgery (Group I), only trauma group (Group II), trauma+CAPE treatment group (Group III), and trauma+methylprednisolone treatment group (Group IV). Histopathological assessment was performed with two staining methods as hematoxylin-eosin (HE) and terminal deoxynucleotidyl Transferase Biotin - dUTP Nick End Labeling (TUNEL). The groups were statistically compared.The apoptotic cells decreased in treatment groups compared with the trauma. CAPE has more anti-apoptotic effect than methylprednisolone. The histological difference between the Group II, and Groups III and IV was statistically significant.CAPE has a positive effect on spinal cord injuries by preventing apoptosis." @default.
• W2419146114 created "2016-06-24" @default.
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• W2419146114 date "2014-01-01" @default.
• W2419146114 modified "2023-09-27" @default.
• W2419146114 title "Histopathologic evaluation of the effects of propolis (cape) in the experimental spinal cord injury" @default.
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• W2419146114 doi "https://doi.org/10.5137/1019-5149.jtn.11255-14.0" @default.
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