FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2419148542> ?p ?o ?g. }

• W2419148542 endingPage "1955" @default.
• W2419148542 startingPage "1946" @default.
• W2419148542 abstract "To determine the acute and long-term effects of low density lipoprotein (LDL) reduction on cholesterol biosynthesis, we studied changes in the cholesterol precursors mevalonic acid (MVA) and lathosterol in patients with heterozygous familial hypercholesterolemia undergoing LDL-apheresis. Long-term LDL-apheresis in eight patients resulted in slight but insignificant increases in plasma MVA levels and lathosterol/cholesterol (L/C) ratios over 18 months. In short-term studies, six patients not on drugs and six patients treated with lovastatin or pravastatin had blood taken immediately before and after LDL-apheresis, and afterwards on days 1, 2, 3, 5, and 7. Plasma L/C ratios and MVA concentration did not change significantly on the first day after LDL-apheresis in those not on statin therapy (1.11 +/- 0.08 vs. 1.40 +/- 0.18, and 9.2 +/- 1.3 vs. 9.1 +/- 0.6 ng/ml, respectively) but increased in the statin-treated group (from 0.78 +/- 0.09 to 1.55 +/- 0.21, P = 0.003 and from 5.0 +/- 0.7 to 11.0 +/- 1.6 ng/ml, P = 0.008, respectively). There was no clear correlation between the changes in either of these precursors and the extent of reduction of total cholesterol by LDL-apheresis, but there was a strong inverse correlation with the post-apheresis LDL-cholesterol level (r = -0.77, P = 0.002 for L/C ratio; r = -0.75, P = 0.003 for MVA). Post-apheresis changes in L/C ratio and MVA were mutually correlated (r = 0.68. P = 0.01). We conclude that LDL-apheresis stimulates cholesterol biosynthesis transiently despite concomitant therapy with an HMG-CoA reductase inhibitor, the degree of stimulation being inversely related to the level to which the LDL-cholesterol was reduced." @default.
• W2419148542 created "2016-06-24" @default.
• W2419148542 creator A5015667427 @default.
• W2419148542 creator A5017234019 @default.
• W2419148542 creator A5022421714 @default.
• W2419148542 creator A5039227030 @default.
• W2419148542 creator A5039396185 @default.
• W2419148542 creator A5074723434 @default.
• W2419148542 creator A5089376763 @default.
• W2419148542 date "1994-11-01" @default.
• W2419148542 modified "2023-09-27" @default.
• W2419148542 title "Acute and chronic effects on cholesterol biosynthesis of LDL-apheresis with or without concomitant HMG-CoA reductase inhibitor therapy." @default.
• W2419148542 cites W1942011559 @default.
• W2419148542 cites W1943560076 @default.
• W2419148542 cites W1964303533 @default.
• W2419148542 cites W1974517335 @default.
• W2419148542 cites W1989739924 @default.
• W2419148542 cites W1998600489 @default.
• W2419148542 cites W2003569742 @default.
• W2419148542 cites W2005965754 @default.
• W2419148542 cites W2006964950 @default.
• W2419148542 cites W2024716729 @default.
• W2419148542 cites W2041330697 @default.
• W2419148542 cites W2042052259 @default.
• W2419148542 cites W2067462604 @default.
• W2419148542 cites W2067635119 @default.
• W2419148542 cites W2071124826 @default.
• W2419148542 cites W2074444487 @default.
• W2419148542 cites W2080212731 @default.
• W2419148542 cites W2084462402 @default.
• W2419148542 cites W2087111382 @default.
• W2419148542 cites W2092381256 @default.
• W2419148542 cites W2093965367 @default.
• W2419148542 cites W2100492905 @default.
• W2419148542 cites W2100680747 @default.
• W2419148542 cites W2116404316 @default.
• W2419148542 cites W2118535904 @default.
• W2419148542 cites W2123332331 @default.
• W2419148542 cites W2127258766 @default.
• W2419148542 cites W2139319270 @default.
• W2419148542 cites W2146875849 @default.
• W2419148542 cites W2148299677 @default.
• W2419148542 cites W2150665883 @default.
• W2419148542 cites W2152103617 @default.
• W2419148542 cites W2317657624 @default.
• W2419148542 doi "https://doi.org/10.1016/s0022-2275(20)39941-7" @default.
• W2419148542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7868973" @default.
• W2419148542 hasPublicationYear "1994" @default.
• W2419148542 type Work @default.
• W2419148542 sameAs 2419148542 @default.
• W2419148542 citedByCount "54" @default.
• W2419148542 countsByYear W24191485422013 @default.
• W2419148542 countsByYear W24191485422014 @default.
• W2419148542 countsByYear W24191485422015 @default.
• W2419148542 countsByYear W24191485422016 @default.
• W2419148542 countsByYear W24191485422017 @default.
• W2419148542 countsByYear W24191485422018 @default.
• W2419148542 countsByYear W24191485422020 @default.
• W2419148542 crossrefType "journal-article" @default.
• W2419148542 hasAuthorship W2419148542A5015667427 @default.
• W2419148542 hasAuthorship W2419148542A5017234019 @default.
• W2419148542 hasAuthorship W2419148542A5022421714 @default.
• W2419148542 hasAuthorship W2419148542A5039227030 @default.
• W2419148542 hasAuthorship W2419148542A5039396185 @default.
• W2419148542 hasAuthorship W2419148542A5074723434 @default.
• W2419148542 hasAuthorship W2419148542A5089376763 @default.
• W2419148542 hasBestOaLocation W24191485421 @default.
• W2419148542 hasConcept C104950815 @default.
• W2419148542 hasConcept C126322002 @default.
• W2419148542 hasConcept C134651460 @default.
• W2419148542 hasConcept C181199279 @default.
• W2419148542 hasConcept C185592680 @default.
• W2419148542 hasConcept C2776738589 @default.
• W2419148542 hasConcept C2777482532 @default.
• W2419148542 hasConcept C2778163477 @default.
• W2419148542 hasConcept C2778751355 @default.
• W2419148542 hasConcept C2779384505 @default.
• W2419148542 hasConcept C3019550498 @default.
• W2419148542 hasConcept C553450214 @default.
• W2419148542 hasConcept C55493867 @default.
• W2419148542 hasConcept C71924100 @default.
• W2419148542 hasConcept C89560881 @default.
• W2419148542 hasConcept C98274493 @default.
• W2419148542 hasConceptScore W2419148542C104950815 @default.
• W2419148542 hasConceptScore W2419148542C126322002 @default.
• W2419148542 hasConceptScore W2419148542C134651460 @default.
• W2419148542 hasConceptScore W2419148542C181199279 @default.
• W2419148542 hasConceptScore W2419148542C185592680 @default.
• W2419148542 hasConceptScore W2419148542C2776738589 @default.
• W2419148542 hasConceptScore W2419148542C2777482532 @default.
• W2419148542 hasConceptScore W2419148542C2778163477 @default.
• W2419148542 hasConceptScore W2419148542C2778751355 @default.
• W2419148542 hasConceptScore W2419148542C2779384505 @default.
• W2419148542 hasConceptScore W2419148542C3019550498 @default.
• W2419148542 hasConceptScore W2419148542C553450214 @default.
• W2419148542 hasConceptScore W2419148542C55493867 @default.
• W2419148542 hasConceptScore W2419148542C71924100 @default.
• W2419148542 hasConceptScore W2419148542C89560881 @default.

• next