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• W2419150381 endingPage "869" @default.
• W2419150381 startingPage "869" @default.
• W2419150381 abstract "Interleukin 24 (IL-24) is an important pleiotropic immunoregulatory cytokine, whose gene is located in human chromosome 1q32-33. IL-24’s signaling pathways have diverse biological functions related to cell differentiation, proliferation, development, apoptosis, and inflammation, placing it at the center of an active area of research. IL-24 is well known for its apoptotic effect in cancer cells while having no such effect on normal cells. IL-24 can also be secreted by both immune and non-immune cells. Downstream effects of IL-24, after binding to the IL-20 receptor, can occur dependently or independently of the JAK/STAT signal transduction pathway, which is classically involved in cytokine-mediated activities. After exogenous addition of IL-24, apoptosis is induced in tumor cells independently of the JAK/STAT pathway. We have shown that IL-24 binds to Sigma 1 Receptor and this event induces endoplasmic reticulum stress, calcium mobilization, reactive oxygen species generation, p38MAPK activity, and ceramide production. Here we review IL-24’s role in autoimmunity, infectious disease response, wound repair, and vascular disease. Detailed understanding of the pleiotropic roles of IL-24 signaling can assist in the selection of more accurate therapeutic approaches, as well as targeting of appropriate cell types in treatment strategy development, and ultimately achieve desired therapeutic effects." @default.
• W2419150381 created "2016-06-24" @default.
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• W2419150381 date "2016-06-02" @default.
• W2419150381 modified "2023-10-05" @default.
• W2419150381 title "Mechanism of Action and Applications of Interleukin 24 in Immunotherapy" @default.
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• W2419150381 cites W1534542499 @default.
• W2419150381 cites W1581636546 @default.
• W2419150381 cites W1723545928 @default.
• W2419150381 cites W1934455124 @default.
• W2419150381 cites W1955488889 @default.
• W2419150381 cites W1966410251 @default.
• W2419150381 cites W1966762423 @default.
• W2419150381 cites W1975206317 @default.
• W2419150381 cites W1978457328 @default.
• W2419150381 cites W1990879645 @default.
• W2419150381 cites W1993690859 @default.
• W2419150381 cites W1994285145 @default.
• W2419150381 cites W1997998868 @default.
• W2419150381 cites W1999481547 @default.
• W2419150381 cites W1999569536 @default.
• W2419150381 cites W2004170517 @default.
• W2419150381 cites W2004993162 @default.
• W2419150381 cites W2005581733 @default.
• W2419150381 cites W2014746498 @default.
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• W2419150381 cites W2016728222 @default.
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• W2419150381 cites W2030099710 @default.
• W2419150381 cites W2033215869 @default.
• W2419150381 cites W2041664710 @default.
• W2419150381 cites W2043578759 @default.
• W2419150381 cites W2043654385 @default.
• W2419150381 cites W2044219441 @default.
• W2419150381 cites W2044943819 @default.
• W2419150381 cites W2053699199 @default.
• W2419150381 cites W2054551045 @default.
• W2419150381 cites W2061442914 @default.
• W2419150381 cites W2063498404 @default.
• W2419150381 cites W2066865593 @default.
• W2419150381 cites W2069323436 @default.
• W2419150381 cites W2069409056 @default.
• W2419150381 cites W2070804167 @default.
• W2419150381 cites W2071632188 @default.
• W2419150381 cites W2075690311 @default.
• W2419150381 cites W2076878346 @default.
• W2419150381 cites W2082082706 @default.
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• W2419150381 cites W2136587728 @default.
• W2419150381 cites W2146400618 @default.
• W2419150381 cites W2151790613 @default.
• W2419150381 cites W2158565324 @default.
• W2419150381 cites W2159548259 @default.
• W2419150381 cites W2160874621 @default.
• W2419150381 cites W2161715870 @default.
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• W2419150381 doi "https://doi.org/10.3390/ijms17060869" @default.
• W2419150381 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4926403" @default.
• W2419150381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27271601" @default.
• W2419150381 hasPublicationYear "2016" @default.
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