Matches in SemOpenAlex for { <https://semopenalex.org/work/W2419184443> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2419184443 endingPage "93" @default.
- W2419184443 startingPage "81" @default.
- W2419184443 abstract "The modulation of cellular iron metabolism depends on the expression of ferritin and transferrin receptor (TfR). These proteins are regulated post-transcriptionally by interaction of specific sequences, termed iron responsive elements (IRE) which are located in the 5' untranslated region (UTR) of ferritin mRNA and 3'UTR of TfR mRNA and a specific cytosolic protein, termed iron responsive element-binding protein (IRE-BP). The liver plays an important role in iron metabolism as a major organ of iron storage. In hepatocytes iron is taken up in the form of transferrin and intercellular iron levels are regulated by IRE/IRE-BP interaction. In spite of the important role of IRE/IRE-BP interaction, the role of it for proliferation and differentiational change in hepatoma cells is not well known. In this study, the author has investigated IRE/IRE-BP interaction and its target protein expression during proliferation and differentiational change of human hepatoblastoma cells (HepG2). This study revealed that the binding activity of IRE-BP to IRE was increased when HepG2 cells were cultured with an iron-chelating agent, deferoxamine (4.5 microM), and it was decreased when cultured with transferrin (100 micrograms/ml) during both proliferation and differentiational change induced by sodium butyrate. Also, the change of TfR expression was correlated with that of IRE-BP. These findings suggest that IRE/IRE-BP interaction may play an important role in the expression of TfR and cellular iron metabolism during proliferation and differentiational change of HepG2 cells." @default.
- W2419184443 created "2016-06-24" @default.
- W2419184443 creator A5049317422 @default.
- W2419184443 date "1996-01-01" @default.
- W2419184443 modified "2023-09-26" @default.
- W2419184443 title "[Analysis of the iron-related proteins during proliferation and differentiational change of human hepatoblastoma cells (HepG2)]." @default.
- W2419184443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8727377" @default.
- W2419184443 hasPublicationYear "1996" @default.
- W2419184443 type Work @default.
- W2419184443 sameAs 2419184443 @default.
- W2419184443 citedByCount "0" @default.
- W2419184443 crossrefType "journal-article" @default.
- W2419184443 hasAuthorship W2419184443A5049317422 @default.
- W2419184443 hasConcept C104317684 @default.
- W2419184443 hasConcept C105580179 @default.
- W2419184443 hasConcept C126322002 @default.
- W2419184443 hasConcept C181199279 @default.
- W2419184443 hasConcept C181674461 @default.
- W2419184443 hasConcept C185592680 @default.
- W2419184443 hasConcept C202751555 @default.
- W2419184443 hasConcept C22814914 @default.
- W2419184443 hasConcept C2776304256 @default.
- W2419184443 hasConcept C2776672577 @default.
- W2419184443 hasConcept C2778319317 @default.
- W2419184443 hasConcept C32264632 @default.
- W2419184443 hasConcept C55493867 @default.
- W2419184443 hasConcept C71924100 @default.
- W2419184443 hasConcept C79879829 @default.
- W2419184443 hasConcept C86803240 @default.
- W2419184443 hasConcept C95444343 @default.
- W2419184443 hasConcept C98539663 @default.
- W2419184443 hasConceptScore W2419184443C104317684 @default.
- W2419184443 hasConceptScore W2419184443C105580179 @default.
- W2419184443 hasConceptScore W2419184443C126322002 @default.
- W2419184443 hasConceptScore W2419184443C181199279 @default.
- W2419184443 hasConceptScore W2419184443C181674461 @default.
- W2419184443 hasConceptScore W2419184443C185592680 @default.
- W2419184443 hasConceptScore W2419184443C202751555 @default.
- W2419184443 hasConceptScore W2419184443C22814914 @default.
- W2419184443 hasConceptScore W2419184443C2776304256 @default.
- W2419184443 hasConceptScore W2419184443C2776672577 @default.
- W2419184443 hasConceptScore W2419184443C2778319317 @default.
- W2419184443 hasConceptScore W2419184443C32264632 @default.
- W2419184443 hasConceptScore W2419184443C55493867 @default.
- W2419184443 hasConceptScore W2419184443C71924100 @default.
- W2419184443 hasConceptScore W2419184443C79879829 @default.
- W2419184443 hasConceptScore W2419184443C86803240 @default.
- W2419184443 hasConceptScore W2419184443C95444343 @default.
- W2419184443 hasConceptScore W2419184443C98539663 @default.
- W2419184443 hasIssue "1" @default.
- W2419184443 hasLocation W24191844431 @default.
- W2419184443 hasOpenAccess W2419184443 @default.
- W2419184443 hasPrimaryLocation W24191844431 @default.
- W2419184443 hasRelatedWork W103198579 @default.
- W2419184443 hasRelatedWork W2016874927 @default.
- W2419184443 hasRelatedWork W2075329038 @default.
- W2419184443 hasRelatedWork W2093427302 @default.
- W2419184443 hasRelatedWork W2123334062 @default.
- W2419184443 hasRelatedWork W2132893346 @default.
- W2419184443 hasRelatedWork W2352772548 @default.
- W2419184443 hasRelatedWork W2419184443 @default.
- W2419184443 hasRelatedWork W2464137413 @default.
- W2419184443 hasRelatedWork W2522337075 @default.
- W2419184443 hasVolume "71" @default.
- W2419184443 isParatext "false" @default.
- W2419184443 isRetracted "false" @default.
- W2419184443 magId "2419184443" @default.
- W2419184443 workType "article" @default.