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- W2419188059 abstract "Objective To assess the relationship between single nucleotide polymorphisms of FceRIαgene and atopic dermatitis. Methods Genomic DNA samples were extracted from peripheral blood of 97 patients with atopic dermatitis and 283 normal human controls. The polymorphism at the distal promoter region of FceRIα gene was determined by PCR-ligase detection reaction assay followed by gene sequencing. Results A G/T polymorphism was observed at position rs61828219 in the promoter region of FceRIα gene, while all the tested individuals were homozygous for T/T at position rs12135235 and A/A at position rs36233780 in the promoter region of FceRIα gene. The mutation frequency at position rs61828219 was 1.04% and 2.17% in patients with AD and normal human controls, respectively (both P > 0.05). Conclusions In the Chinese Han population, there is a G/T polymorphism at position rs61828219 in FceRIα gene promoter region, which is unlikely related to the development of AD; however, no polymorphism is detected at position rs12135235 or rs36233780.Key words: Dermatitis atopic; Genes FceRI; Polymorphism, single nucleotide" @default.
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- W2419188059 date "2010-09-15" @default.
- W2419188059 modified "2023-09-24" @default.
- W2419188059 title "Polymorphisms of the high-affinity receptor for IgE alpha-chain (FcεRIα) gene in patients with atopic dermatitis." @default.
- W2419188059 doi "https://doi.org/10.3760/cma.j.issn.0412-4030.2010.09.010" @default.
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